Herder, V.; Kummrow, M.; Leeb, Tosso; Sewell, A. C.; Hansmann, F.; Lehmbecker, A.; Wohlsein, P.; Baumgärtner, W. (2014). Polycystic Kidneys and GM2 Gangliosidosis-Like Disease in Neonatal Springboks (Antidorcas marsupialis). Veterinary pathology, 52(3), pp. 543-552. American College of Veterinary Pathologists 10.1177/0300985814549210
Full text not available from this repository. (Request a copy)Clinical, gross, histopathologic, electron microscopic findings and enzymatic analysis of 4 captive, juvenile springboks (Antidorcas marsupialis) showing both polycystic kidneys and a storage disease are described. Springbok offspring (4 of 34; 12%) were affected by either one or both disorders in a German zoo within a period of 5 years (2008-2013). Macroscopic findings included bilaterally severely enlarged kidneys displaying numerous cysts in 4 animals and superior brachygnathism in 2 animals. Histopathologically, kidneys of 4 animals displayed cystic dilation of the renal tubules. In addition, abundant cytoplasmic vacuoles with a diameter ranging from 2 to 10 μm in neurons of the central and peripheral nervous system, hepatocytes, thyroid follicular epithelial cells, pancreatic islets of Langerhans and renal tubular cells were found in 2 springbok neonates indicative of an additional storage disease. Ultrastructurally, round electron-lucent vacuoles, up to 4 μm in diameter, were present in neurons. Enzymatic analysis of liver and kidney tissue of 1 affected springbok revealed a reduced activity of total hexosaminidase (Hex) with relatively increased HexA activity at the same level of total Hex, suggesting a hexosaminidase defect. Pedigree analysis suggested a monogenic autosomal recessive inheritance for both diseases. In summary, related springboks showed 2 different changes resembling both polycystic kidney and a GM2 gangliosidosis similar to the human Sandhoff disease. Whether the simultaneous occurrence of these 2 entities represents an incidental finding or has a genetic link needs to be investigated in future studies.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Leeb, Tosso |
Subjects: |
600 Technology > 630 Agriculture 500 Science > 590 Animals (Zoology) 600 Technology > 610 Medicine & health |
ISSN: |
0300-9858 |
Publisher: |
American College of Veterinary Pathologists |
Language: |
English |
Submitter: |
Tosso Leeb |
Date Deposited: |
29 Jan 2015 12:04 |
Last Modified: |
05 Dec 2022 14:39 |
Publisher DOI: |
10.1177/0300985814549210 |
PubMed ID: |
25232033 |
Uncontrolled Keywords: |
Antidorcas marsupialis, autosomal-recessive, GM2 gangliosidosis, polycystic kidney disease, hexosaminidase, neurons, springbok, storage disease |
URI: |
https://boris.unibe.ch/id/eprint/62426 |
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