Prevalence of paunch calf syndrome carriers in Italian Romagnola cattle.

Murgiano, Leonardo; Drögemüller, Cord; Sbarra, F; Bolcato, M; Gentile, A (2014). Prevalence of paunch calf syndrome carriers in Italian Romagnola cattle. Veterinary journal, 200(3), pp. 459-461. Elsevier 10.1016/j.tvjl.2014.03.020

[img] Text
1-s2.0-S1090023314001208-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (995kB) | Request a copy

The term 'paunch calf syndrome' encompasses the multi-organic lethal developmental dysplasia reported in the Romagnola breed of cattle and is characterised by facial deformities, an enlarged and floating abdomen containing considerable abdominal effusion, and hepatic fibrosis. Paunch calf syndrome is caused by a missense mutation in the KDM2B gene (c.2503G>A) that is thought to lead to an amino acid exchange (p.D835N). In this study, the prevalence of carriers of the mutant KDM2B allele (and thus the frequency of the allele) was assessed in selected subpopulations of Romagnola cattle. The prevalence of carriers within top-ranked Romagnola sires over the years 2007-2012 was 29.3% (allele frequency 14.6%). In young bull calves, 30.9% were carriers with an allele frequency of 15.4%.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Murgiano, Leonardo and Drögemüller, Cord

Subjects:

600 Technology > 630 Agriculture
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

1090-0233

Publisher:

Elsevier

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

03 Feb 2015 14:55

Last Modified:

12 Oct 2015 15:21

Publisher DOI:

10.1016/j.tvjl.2014.03.020

PubMed ID:

24792452

Uncontrolled Keywords:

Bovine, Genetic diseases, KDM2B, Paunch calf syndrome, Romagnola breed

BORIS DOI:

10.7892/boris.62464

URI:

https://boris.unibe.ch/id/eprint/62464

Actions (login required)

Edit item Edit item
Provide Feedback