[Adsorption therapy in sepsis.]

Hasper, D; Schefold, Joerg C.; Jörres, A (2015). [Adsorption therapy in sepsis.]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 110(4), pp. 272-277. Springer 10.1007/s00063-014-0415-7

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BACKGROUND The activation of multiple pro- and anti-inflammatory mediators is a key feature in the pathophysiology of sepsis. Many of these mediators may directly contribute to organ dysfunction and determine disease severity. So far our ability to modulate these upregulated mediator pathways is very limited. Therefore the adsorption of such mediators via an extracorporeal circuit may be a beneficial intervention during sepsis. OBJECTIVES Recent technical innovations have made this intervention feasible. Both systems for exclusive mediator adsorption and for adsorption beside a conventional renal replacement therapy are now available. Some of the membranes can adsorb a broad range of mediators by rather unspecific binding, whereas others specifically adsorb endotoxin or mediators. DISCUSSION Whilst biochemical efficacy could be demonstrated by some of the systems, controlled and randomized studies demonstrating improved clinical endpoints are still lacking. Therefore the use of such therapies outside clinical studies cannot yet be recommended.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Schefold, Joerg C.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2193-6226

Publisher:

Springer

Language:

German

Submitter:

Alessandra Angelini

Date Deposited:

16 Feb 2015 15:35

Last Modified:

29 Oct 2015 09:25

Publisher DOI:

10.1007/s00063-014-0415-7

PubMed ID:

25248547

BORIS DOI:

10.7892/boris.63311

URI:

https://boris.unibe.ch/id/eprint/63311

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