Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas.

Schmidt, T; Sicic, L; Blank, S; Becker, K; Weichert, W; Bruckner, T; Parakonthun, T; Langer, Rupert; Büchler, M W; Siewert, J-R; Lordick, F; Ott, K (2014). Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas. British journal of cancer, 110(7), pp. 1712-1720. Nature Publishing Group 10.1038/bjc.2014.94

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BACKGROUND Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional and gastric) cancer. This exploratory retrospective study analyses independent prognostic factors within a large patient cohort after preoperative chemotherapy including clinical and histopathological factors. METHODS In all, 850 patients presenting with oesophagogastric cancer staged cT3/4 Nany cM0/x were treated with neoadjuvant chemotherapy followed by resection in two academic centres. Patient data were documented in a prospective database and retrospectively analysed. RESULTS Of all factors prognostic on univariate analysis, only clinical response, complications, ypTNM stage, and R category were independently prognostic (P<0.01) on multivariate analysis. Tumour localisation and signet ring cells were independently prognostic only when investigator-dependent clinical response evaluation was excluded from the multivariate model. Histopathological tumour regression correlates with tumour grading, Laurén classification, clinical response, ypT, ypN, and R categories but was not identified as an independent prognostic factor. Within R0-resected patients only surgical complications and ypTNM stage were independent prognostic factors. CONCLUSIONS Only established prognostic factors like ypTNM stage, R category, and complications were identified as independent prognostic factors in resected patients after neoadjuvant chemotherapy. In contrast, histopathological tumour regression was not found as an independent prognostic marker.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Langer, Rupert


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health




Nature Publishing Group




Doris Haefelin

Date Deposited:

23 Feb 2015 14:15

Last Modified:

07 Apr 2015 08:58

Publisher DOI:


PubMed ID:





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