Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells

Batliner, Jasmin; Buehrer, Emanuel; Fey, Martin F; Tschan, Mario P (2012). Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells. Leukemia research, 36(2), pp. 237-40. Amsterdam: Elsevier 10.1016/j.leukres.2011.10.006

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MicroRNAs can influence hematopoietic cell lineage commitment and aberrant expression of hematopoietic miRNAs contributes to AML pathology. We found that miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
UniBE Contributor:	Fey, Martin, Tschan, Mario Paul
ISSN:	0145-2126
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:20
Last Modified:	05 Dec 2022 14:05
Publisher DOI:	10.1016/j.leukres.2011.10.006
PubMed ID:	22093444
Web of Science ID:	000298658600021
URI:	https://boris.unibe.ch/id/eprint/6455 (FactScience: 211421)