 | Up a level |
Rafiq, Sreoshee; Mungure, Irene; Banz, Yara; Niklaus, Nicolas J.; Kaufmann, Thomas; Müller, Stefan; Jacquel, Arnaud; Robert, Guillaume; Auberger, Patrick; Torbett, Bruce E; Muller, Sylviane; Tschan, Mario P.; Humbert, Magali (2024). HSPA8 Chaperone Complex Drives Chaperone-Mediated Autophagy Regulation in Acute Promyelocytic Leukemia Cell Differentiation. Pharmacology, 109(4), pp. 216-230. Karger 10.1159/000537864
Mandhair, Harpreet K; Radpour, Ramin; Westerhuis, Mira; Banz, Yara; Humbert, Magali; Arambasic, Miroslav; Dengjel, Jörn; Davies, Andrew; Tschan, Mario P; Novak, Urban (2024). Analysis of autophagy in DLBCL reveals subtype-specific differences and the preferential targeting of ULK1 inhibition in GCB-DLBCL provides a rationale as a new therapeutic approach. Leukemia, 38(2), pp. 424-429. Nature Publishing Group 10.1038/s41375-024-02147-4
Seiler, Kristina; Rafiq, Sreoshee; Tschan, Mario P (2023). Isoform-specific, Semi-quantitative Determination of Highly Homologous Protein Levels via CRISPR-Cas9-mediated HiBiT Tagging. Bio-protocol, 13(14), e4777. bio-protocol 10.21769/BioProtoc.4777
Losmanová, Tereza; Tschan, Mario P; Galván, José A; Berezowska, Sabina (2023). Immunohistochemical Detection of the Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Formalin-Fixed and Paraffin-Embedded Tissues. Methods in molecular biology, 2566, pp. 141-147. Springer 10.1007/978-1-0716-2675-7_11
Pied, Noémie; Daussy, Coralie F; Denis, Zoé; Ragues, Jessica; Faure, Muriel; Iggo, Richard; Tschan, Mario P; Roger, Benoit; Rayne, Fabienne; Wodrich, Harald (2022). TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape. PLoS pathogens, 18(7), e1010736. Public Library of Science 10.1371/journal.ppat.1010736
Seiler, Kristina; Humbert, Magali; Minder, Petra; Mashimo, Iris; Schläfli, Anna M; Krauer, Deborah; Federzoni, Elena A; Vu, Bich; Moresco, James J; Yates, John R; Sadowski, Martin C; Radpour, Ramin; Kaufmann, Thomas; Sarry, Jean-Emmanuel; Dengjel, Joern; Tschan, Mario P; Torbett, Bruce E (2022). Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Cell death & disease, 13(5), p. 448. Springer Nature 10.1038/s41419-022-04891-w
Gianni’, Maurizio; Goracci, Laura; Schlaefli, Anna; Di Veroli, Alessandra; Kurosaki, Mami; Guarrera, Luca; Bolis, Marco; Foglia, Marika; Lupi, Monica; Tschan, Mario; Cruciani, Gabriele; Terao, Mineko; Garattini, Enrico (2022). Role of cardiolipins, mitochondria, and autophagy in the differentiation process activated by all-trans retinoic acid in acute promyelocytic leukemia. Cell death & disease, 13(1), p. 30. Nature Publishing Group 10.1038/s41419-021-04476-z
Gavini, J; Leuenberger, D; Yarahmadov, T; Dommann, N; Keogh, A; Melin, N; Tschan, M; Nuoffer, J-M; Hertig, D; Zuber, B; Odriozola, A; Tombolini, R; Chrétien, M; Mbikay, M; Candinas, D; Stroka, D (2022). Intracellular Proprotein convertase subtilisin/kexin type 9: Recruitment and regulatory role in mitochondrial architecture and bioenergetic. British journal of surgery, 109(Supplement_3) Oxford University Press 10.1093/bjs/znac176.003
Losmanová, Tereza; Zens, Philipp; Scherz, Amina; Schmid, Ralph; Tschan, Mario P.; Berezowska, Sabina Anna (2021). Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy. Cells, 10(10) MDPI 10.3390/cells10102731
Rafiq, Sreoshee; McKenna, Sharon L; Muller, Sylviane; Tschan, Mario; Humbert, Magali (2021). Lysosomes in acute myeloid leukemia: potential therapeutic targets? Leukemia, 35(10), pp. 2759-2770. Springer Nature 10.1038/s41375-021-01388-x
Yang, Zhang; Liang, Shun-Qing; Saliakoura, Maria; Yang, Haitang; Vassella, Erik; Konstantinidou, Georgia; Tschan, Mario; Hegedüs, Balazs; Zhao, Liang; Gao, Yanyun; Xu, Duo; Deng, Haibin; Marti, Thomas M; Kocher, Gregor J; Wang, Wenxiang; Schmid, Ralph A; Peng, Ren-Wang (2021). Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS-mutant cancer. EMBO molecular medicine, 13(9), e13193. EMBO Press 10.15252/emmm.202013193
Humbert, Magali; Seiler, Kristina; Mosimann, Severin; Rentsch, Vreni; Sharma, Katyayani; Pandey, Amit Vikram; McKenna, Sharon L.; Tschan, Mario P. (2021). Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy. Cell death and differentiation, 28(8), pp. 2465-2481. Springer Nature 10.1038/s41418-021-00768-1
Niklaus, Nicolas J; Tokarchuk, Igor; Zbinden, Mara; Schläfli, Anna M; Maycotte, Paola; Tschan, Mario P. (2021). The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment. Cells, 10(6) MDPI 10.3390/cells10061447
Schläfli, Anna M; Tokarchuk, Igor; Parejo, Sarah; Jutzi, Susanne; Berezowska, Sabina; Engedal, Nikolai; Tschan, Mario P. (2021). ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells. Scientific reports, 11(1), p. 9011. Springer Nature 10.1038/s41598-021-87966-6
Seiler, Kristina; Tschan, Mario P. (2021). Autophagy and coronavirus infection - a Trojan horse or Achilles heel? Swiss medical weekly, 151(w20468), w20468. EMH Media 10.4414/smw.2021.20468
Losmanová, Tereza; Janser, Félice A; Humbert, Magali; Tokarchuk, Igor; Schläfli, Anna M; Neppl, Christina; Schmid, Ralph A; Tschan, Mario P; Langer, Rupert; Berezowska, Sabina (2021). Corrigendum to "Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung". Oxidative medicine and cellular longevity, 2021, p. 9846486. Hindawi 10.1155/2021/9846486
Tokarchuk, Igor; Janser, Félice A.; Schläfli, Anna M.; Pinto, Marta Teixeira; Humbert, Magali; Niklaus, Nicolas J.; Berezowska, Sabina; Langer, Rupert; Tschan, Mario P. (2021). Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability. Biochemical and biophysical research communications, 569, pp. 47-53. Elsevier 10.1016/j.bbrc.2021.06.082
Dommann, Noëlle; Sánchez Taltavull, Daniel; Eggs, Linda; Birrer, Fabienne Esther; Brodie, Tess; Salm, Lilian; Baier, Felix Alexander; Medova, Michaela; Humbert, Magali; Tschan, Mario; Beldi, Guido; Candinas, Daniel; Stroka, Deborah (2020). The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer. Cancers, 12(7) MDPI AG 10.3390/cancers12071913
Orfali, Nina; Shan-Krauer, Deborah; O'Donovan, Tracey R; Mongan, Nigel P; Gudas, Lorraine J; Cahill, Mary R; Tschan, Mario P.; McKenna, Sharon L (2020). Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells. Molecular oncology, 14(6), pp. 1297-1309. Wiley 10.1002/1878-0261.12614
Bonam, Srinivasa Reddy; Bayry, Jagadeesh; Tschan, Mario; Muller, Sylviane (2020). Progress and Challenges in The Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo. Cells, 9(5) MDPI 10.3390/cells9051321
Humbert, Magali; Morán, María; de la Cruz-Ojeda, Patricia; Muntané, Jordi; Wiedmer, Tabea; Apostolova, Nadezda; McKenna, Sharon L; Velasco, Guillermo; Balduini, Walter; Eckhart, Leopold; Janji, Bassam; Sampaio-Marques, Belém; Ludovico, Paula; Žerovnik, Eva; Langer, Rupert; Perren, Aurel; Engedal, Nikolai; Tschan, Mario (2020). Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot. Biology, 9(3), pp. 1-24. MDPI 10.3390/biology9030059
Losmanová, Tereza; Janser, Félice A.; Humbert, Magali; Tokarchuk, Igor; Schläfli, Anna M.; Neppl, Christina; Schmid, Ralph; Tschan, Mario P.; Langer, Rupert; Berezowska, Sabina (2020). Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung. Oxidative medicine and cellular longevity, 2020, p. 8506572. Hindawi 10.1155/2020/8506572
Gavini, Jacopo; Dommann, Noëlle; Jakob, Manuel O.; Keogh, Adrian; Bouchez, Laure C; Karkampouna, Sofia; Kruithof-de Julio, Marianna; Medova, Michaela; Zimmer, Yitzhak; Schläfli, Anna M; Tschan, Mario P.; Candinas, Daniel; Stroka, Deborah; Banz, Vanessa (2019). Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma. Cell death & disease, 10(10), p. 749. Springer Nature 10.1038/s41419-019-1989-z
Adams, Olivia; Janser, Félice A.; Dislich, Bastian; Berezowska, Sabina; Humbert, Magali; Seiler, Christian A.; Kröll, Dino; Slotta-Huspenina, Julia; Feith, Marcus; Ott, Katja; Tschan, Mario P.; Langer, Rupert (2019). Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS ONE, 14(10), e0224832. Public Library of Science 10.1371/journal.pone.0224832
Djavaheri-Mergny, Mojgan; Giuriato, Sylvie; Tschan, Mario; Humbert, Magali (2019). Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma. Cells, 8(2) MDPI 10.3390/cells8020103
Parejo, Sarah; Tschan, Mario; Muraro, Manuele G; Garattini, Enrico; Spagnoli, Giulio C; Schläfli, Anna M (2019). Assessing Autophagy During Retinoid Treatment of Breast Cancer Cells. In: Ray, Swapan K. (ed.) Retinoid and Rexinoid Signaling. Methods in molecular biology: Vol. 2019 (pp. 237-256). Springer 10.1007/978-1-4939-9585-1_17
Janser, Ariane F.; Tschan, Mario P.; Langer, Rupert (2019). The role of autophagy in HER2-targeted therapy. Swiss medical weekly, 149(149), w20138. EMH Media 10.4414/smw.2019.20138
Janser, Félice A.; Ney, Patricia; Teixeira Pinto, Marta; Langer, Rupert; Tschan, Mario P. (2019). The Chick Chorioallantoic Membrane (CAM) Assay as a Three-dimensional Model to Study Autophagy in Cancer Cells. Bio-protocol, 9(13) bio-protocol 10.21769/BioProtoc.3290
Janser, Félice A.; Adams, Olivia Joan; Bütler, Vanessa; Bill, Anna Magdalena; Dislich, Bastian; Seiler, Christian A.; Kröll, Dino; Langer, Rupert; Tschan, Mario (2018). Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells. International journal of molecular sciences, 19(10) MDPI 10.3390/ijms19103069
Graule, Janina; Uth-Gottardi, Kristin; Fischer, Elia Luca; Centeno Ramos, Irene; Galván Hernández, José Alberto; Eichmann, Micha David; Rau, Tilman; Langer, Rupert; Dawson, Heather; Nitsche, Ulrich; Traeger, Peter; Berger, Martin Dave; Schnüriger, Beat; Hädrich, Marion; Studer, Peter; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2018). CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway. Clinical epigenetics, 10(1), p. 120. Springer 10.1186/s13148-018-0548-2
Niklaus, Nicolas Jan; Humbert, Magali; Tschan, Mario (2018). Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression. Biochemical and biophysical research communications, 503(4), pp. 2800-2806. Academic Press 10.1016/j.bbrc.2018.08.042
Jin, Jing; Britschgi, Adrian; Schläfli, Anna M.; Humbert, Magali; Shan-Krauer, Deborah; Batliner, Jasmin; Federzoni, Elena A.; Ernst, Marion; Torbett, Bruce E.; Yousefi, Shida; Simon, Hans-Uwe; Tschan, Mario (2018). Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxidative medicine and cellular longevity, 2018, p. 1482795. Hindawi 10.1155/2018/1482795
Langer, Rupert; Neppl, Christina; Keller, Manuel; Schmid, Ralph; Tschan, Mario; Berezowska, Sabina Anna (2018). Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas. Cancers, 10(9), p. 281. MDPI AG 10.3390/cancers10090281
Adams, Olivia; Janser, Félice A.; Dislich, Bastian; Berezowska, Sabina; Humbert, Magali; Seiler, Christian A.; Kroell, Dino; Slotta-Huspenina, Julia; Feith, Marcus; Ott, Katja; Tschan, Mario P.; Langer, Rupert (2018). A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS ONE, 13(6), e0197610. Public Library of Science 10.1371/journal.pone.0197610
Humbert, Magali; Federzoni, Elena; Tschan, Mario (2017). Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. Journal of leukocyte biology, 102(6), pp. 1357-1370. Society for Leukocyte Biology 10.1189/jlb.1A0317-132R
Wiedmer, Tabea; Blank, Annika; Pantasis, Sophia; Normand, Lea Elena Haaning; Bill, Ruben; Krebs, Philippe; Tschan, Mario; Marinoni, Ilaria; Perren, Aurel (2017). Autophagy inhibition improves sunitinib efficacy in pancreatic neuroendocrine tumors via a lysosome-dependent mechanism. Molecular cancer therapeutics, 16(11), pp. 2502-2515. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-17-0136
Schläfli, Anna; Isakson, Pauline; Garattini, E; Simonsen, Anne; Tschan, Mario (2017). The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells. Scientific Reports, 7(1), p. 12980. Nature Publishing Group 10.1038/s41598-017-12734-4
Niklaus, Monique; Adams, Olivia Joan; Berezowska, Sabina Anna; Zlobec, Inti; Graber, Franziska; Slotta-Huspenina, Julia; Nitsche, Ulrich; Rosenberg, Robert; Tschan, Mario; Langer, Rupert (2017). Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer. OncoTarget, 8(33), pp. 54604-54615. Impact Journals LLC 10.18632/oncotarget.17554
Bakula, Daniela; Müller, Amelie J; Zuleger, Theresia; Takacs, Zsuzsanna; Franz-Wachtel, Mirita; Thost, Ann-Katrin; Brigger, Daniel; Tschan, Mario; Frickey, Tancred; Robenek, Horst; Macek, Boris; Proikas-Cezanne, Tassula (2017). WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. Nature communications, 8(15637), p. 15637. Nature Publishing Group 10.1038/ncomms15637
Rothschild, Sacha; Gautschi, Oliver; Batliner, Jasmin; Gugger, Mathias; Fey, Martin; Tschan, Mario (2017). MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors. Lung cancer, 107, pp. 73-83. Elsevier 10.1016/j.lungcan.2016.06.004
Haimovici, Aladin; Humbert, Magali; Federzoni, Elena A; Shan-Krauer, Deborah; Brunner, Thomas; Frese, Steffen; Kaufmann, Thomas; Torbett, Bruce E; Tschan, Mario (2017). PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression. Cell death and differentiation, 24(5), pp. 866-877. Nature Publishing Group 10.1038/cdd.2017.40
Langsch, Stephanie; Baumgartner, Ulrich; Haemmig, Stefan; Schlup, Cornelia; Schäfer, Stephan; Berezowska, Sabina Anna; Rieger, Gregor; Dorn, Patrick; Tschan, Mario; Vassella, Erik (2016). miR-29b Mediates NF-κB Signaling in KRAS-Induced Non-Small Cell Lung Cancers. Cancer research, 76(14), pp. 4160-4169. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-15-2580
Schläfli, Anna; Adams, Olivia Joan; Galván Hernández, José Alberto; Gugger, Mathias; Savic Prince, Spasenija; Bubendorf, Lukas; Schmid, Ralph; Becker, Karl-Friedrich; Tschan, Mario; Langer, Rupert; Berezowska, Sabina Anna (2016). Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. OncoTarget, 7(26), pp. 39544-39555. Impact Journals LLC 10.18632/oncotarget.9647
Adams, Olivia Joan; Dislich, Bastian; Berezowska, Sabina Anna; Schläfli, Anna; Seiler, Christian A.; Kröll, Dino; Tschan, Mario; Langer, Rupert (2016). Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. OncoTarget, 7(26), pp. 39241-39255. Impact Journals LLC 10.18632/oncotarget.9649
Weber, Martin R; Zuka, Masahiko; Lorger, Mihaela; Tschan, Mario; Torbett, Bruce E; Zijlstra, Andries; Quigley, James P; Staflin, Karin; Eliceiri, Brian P; Krueger, Joseph S; Marchese, Patrizia; Ruggeri, Zaverio M; Felding, Brunhilde H (2016). Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream. Thrombosis research, 140(Suppl1), S27-36. Elsevier 10.1016/S0049-3848(16)30095-0
Berezowska, Sabina Anna; Schläfli, Anna; Adams, O; Galván Hernández, José Alberto; Bubendorf, L; Prince, S Savic; Schmid, Ralph; Gugger, M; Tschan, Mario; Langer, Rupert (2016). 25P Autophagy in early stage NSCLC - prognostic significance of the autophagy markers p62 and LC3B. Journal of thoracic oncology, 11(4Suppl), S66-S66. Elsevier 10.1016/S1556-0864(16)30139-3
Wampfler, Julian; Federzoni, Elena; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2016). The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation. Leukemia research, 41, pp. 96-102. Elsevier 10.1016/j.leukres.2015.12.006
Simon, Hans-Uwe; Tschan, Mario P.; Bütikofer, Peter (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. Landes Bioscience 10.1080/15548627.2015.1100356
Mikami, K.; Medova, Michaela; Nisa Hernandez, Lluis; Francica, Paola; Glück, Astrid Andreina; Tschan, Mario; Blaukat, A.; Bladt, F.; Aebersold, Daniel; Zimmer, Yitzhak (2015). Impact of p53 Status on Radiosensitization of Tumor Cells by MET Inhibition-Associated Checkpoint Abrogation. Molecular cancer research, 13(12), pp. 1544-1553. American Association for Cancer Research AACR 10.1158/1541-7786.MCR-15-0022
Tschan, Mario P.; Federzoni, Elena A.; Haimovici, Aladin; Britschgi, Christian; Moser, Bettina A.; Jin, Jing; Reddy, Venkateshwar A.; Sheeter, Dennis A.; Fischer, Kimberlee M.; Sun, Peiqing; Torbett, Bruce E. (2015). Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation. Biochimica et biophysica acta - gene regulatory mechanisms, 1849(9), pp. 1198-1208. Elsevier 10.1016/j.bbagrm.2015.07.009
Wampfler, Julian; Federzoni, Elena; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2015). Low DICER1 expression is associated with attenuated neutrophil differentiation and autophagy of NB4 APL cells. Journal of leukocyte biology, 98(3), pp. 357-363. Society for Leukocyte Biology 10.1189/jlb.1AB0514-258R
Orfali, Nina; O'Donovan, Tracey R; Nyhan, Michelle J; Britschgi, Adrian; Tschan, Mario; Cahill, Mary R; Mongan, Nigel P; Gudas, Lorraine J; McKenna, Sharon L (2015). Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation. Experimental hematology, 43(9), 781-793.e2. Elsevier 10.1016/j.exphem.2015.04.012
Delgado Tascón, Julia; Adrian, Jonas; Kopp, Kathrin; Scholz, Philipp; Tschan, Mario; Kuespert, Katharina; Hauck, Christof R (2015). The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. Journal of leukocyte biology, 97(3), pp. 521-531. Society for Leukocyte Biology 10.1189/jlb.2AB0813-449RR
Galván Hernández, José Alberto; Helbling, Melina; Kölzer, Viktor; Tschan, Mario; Berger, Martin Dave; Hädrich, Marion; Schnüriger, Beat; Karamitopoulou, Evanthia; Dawson, Heather; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2015). TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. OncoTarget, 6(2), pp. 874-885. Impact Journals LLC 10.18632/oncotarget.2716
Brockmann, Anette; Bluwstein, A; Kögel, A; May, S; Marx, A; Tschan, Mario; Brunner, Thomas (2015). Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation. Cell death & disease, 6(6), e1778-e1778. Nature Publishing Group 10.1038/cddis.2015.137
Brigger, D.; Schläfli, Anna; Garattini, E.; Tschan, M. P. (2015). Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. Cell death & disease, 6(e1861), e1861. Nature Publishing Group 10.1038/cddis.2015.236
Geering, Barbara; Zokouri, Zina; Hürlemann, Samuel; Gerrits, Bertran; Ausländer, David; Britschgi, Adrian; Tschan, Mario; Simon, Hans-Uwe; Fussenegger, Martin (2015). Identification of Novel Death-Associated Protein Kinase 2 Interaction Partners by Proteomic Screening Coupled with Bimolecular Fluorescence Complementation. Molecular and cellular biology, 36(1), pp. 132-143. American Society for Microbiology 10.1128/MCB.00515-15
Federzoni, Elena; Gloor, Severin; Jin, Jing; Krauer, Deborah; Fey, Martin; Torbett, Bruce E; Tschan, Mario (2015). Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leukemia research reports, 4(1), pp. 32-35. Elsevier 10.1016/j.lrr.2015.04.002
Schläfli, Anna; Berezowska, Sabina Anna; Adams, Olivia Joan; Langer, Rupert; Tschan, Mario (2015). Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. European journal of histochemistry, 59(2), p. 2481. Luigi Ponzio 10.4081/ejh.2015.2481
Trocoli, A; Bensadoun, P; Richard, E; Labrunie, G; Merhi, F; Schläfli, Anna; Brigger, Daniel; Souquere, S; Pierron, G; Pasquet, J-M; Soubeyran, P; Reiffers, J; Ségal-Bendirdjian, E; Tschan, Mario; Djavaheri-Mergny, M (2014). p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells. Cell death and differentiation, 21(12), pp. 1852-1861. Nature Publishing Group 10.1038/cdd.2014.102
Haimovici, Aladin; Brigger, Daniel; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2014). Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation. Leukemia research, 38(9), pp. 1041-1047. Elsevier 10.1016/j.leukres.2014.06.010
Helbling, Melina; Lukesch, Anne Carolin; Haimovici, Aladin; Karamitopoulou, Evanthia; Berger, Martin Dave; Hädrich, Marion; Mallaev, Makhmud; Schnüriger, Beat; Kölzer, Viktor; Dawson, Heather; Borner, Markus; Langer, Rupert; Rosenberg, Robert; Nitsche, Ulrich; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2014). Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients. OncoTarget, 5(13), pp. 4671-4682. Impact Journals LLC
Pfisterer, Simon G; Bakula, Daniela; Frickey, Tancred; Cezanne, Alice; Brigger, Daniel; Tschan, Mario; Robenek, Horst; Proikas-Cezanne, Tassula (2014). Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells. Journal of lipid research, 55(7), pp. 1267-1278. American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M046359
Stutz, Emanuel; Gautschi, Oliver; Fey, Martin F.; Gugger, Mathias; Tschan, Mario; Rothschild, Sacha I. (2014). Crizotinib inhibits migration and expression of ID1 in MET-positive lung cancer cells: implications for MET targeting in oncology. Future oncology, 10(2), pp. 211-217. Future Medicine Ltd. 10.2217/fon.13.179
Humbert, Magali; Federzoni, Elena; Britschgi, Adrian; Schläfli, Anna; Valk, PJ; Kaufmann, Thomas; Haferlach, T.; Behre, G.; Simon, Hans-Uwe; Torbett, BE; Fey, Martin; Tschan, Mario (2014). The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL. Journal of leukocyte biology, 95(1), pp. 83-93. Society for Leukocyte Biology 10.1189/jlb.1112608
Brigger, Daniel; Proikas-Cezanne, T; Tschan, Mario (2014). WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. Cell death & disease, 5(e1315), e1315. Nature Publishing Group 10.1038/cddis.2014.261
Haemmig, Stefan; Baumgartner, Ulrich; Glück, Astrid; Zbinden, Samuel; Tschan, Mario; Kappeler, Andreas; Mariani, L; Vajtai, Istvan; Vassella, Erik (2014). miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas. Cell death & disease, 5(e1279), e1279. Nature Publishing Group 10.1038/cddis.2014.245
Federzoni, Elena; Humbert, Magali; Torbett, Bruce E; Behre, Gerhard; Fey, Martin; Tschan, Mario (2014). CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation. Scientific Reports, 4(1), p. 4261. Nature Publishing Group 10.1038/srep04261
Portmann, Simone; Fahrner, René; Lechleiter, Antje; Keogh, Adrian; Overney, Sarah; Lämmle, Alexander; Mikami, Kei; Montani, Matteo; Tschan, Mario; Candinas, Daniel; Keogh-Stroka, Deborah M. (2013). Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Molecular cancer therapeutics, 12(4), pp. 499-508. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-12-0700
Humbert, Magali; Medova, Michaela; Aebersold, Daniel; Blaukat, Andree; Bladt, Friedhelm; Fey, Martin; Zimmer, Yitzhak; Tschan, Mario P. (2013). Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. Biochemical and biophysical research communications, 431(2), pp. 264-269. Academic Press 10.1016/j.bbrc.2012.12.120
Wojtalla, Anna; Fischer, Barbara; Kotelevets, Nataliya; Mauri, Francesco A; Sobek, Jens; Rehrauer, Hubert; Wotzkow, Carlos; Tschan, Mario P; Seckl, Michael J; Zangemeister-Wittke, Uwe; Arcaro, Alexandre (2013). Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer. Clinical cancer research, 19(1), pp. 96-105. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-1138
He, Zhaoyue; Liu, He; Agostini, M.; Yousefi, Shida; Perren, Aurel; Tschan, Mario; Mak, TW; Melino, G:; Simon, Hans-Uwe (2013). p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene. Cell death and differentiation, 20(10), pp. 1415-1424. Nature Publishing Group 10.1038/cdd.2013.104
Brigger, Daniel; Torbett, Bruce E.; Chen, Joy; Fey, Martin; Tschan, Mario (2013). Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation. Biochemical and biophysical research communications, 438(2), pp. 283-288. Academic Press 10.1016/j.bbrc.2013.07.056
Federzoni, Elena A.; Humbert, Magali; Valk, Peter J. M.; Behre, Gerhard; Leibundgut, Elisabeth O.; Torbett, Bruce E; Fey, Martin F.; Tschan, Mario (2013). The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients. British journal of haematology, 160(6), pp. 855-859. Oxford: Wiley-Blackwell 10.1111/bjh.12170
Batliner, Jasmin; Buehrer, Emanuel; Federzoni, Elena A; Jenal, Mathias; Tobler, Andreas; Torbett, Bruce E; Fey, Martin F; Tschan, Mario P (2012). Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells. British journal of haematology, 157(2), pp. 270-274. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2011.08964.x
Batliner, Jasmin; Buehrer, Emanuel; Fey, Martin F; Tschan, Mario P (2012). Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells. Leukemia research, 36(2), pp. 237-40. Amsterdam: Elsevier 10.1016/j.leukres.2011.10.006
Laemmle, Alexander; Lechleiter, Antje; Roh, Vincent; Schwarz, Christa; Portmann, Simone; Furer, Cynthia; Keogh, Adrian; Tschan, Mario P; Candinas, Daniel; Vorburger, Stephan A; Stroka, Deborah (2012). Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions. PLoS ONE, 7(3), e33433. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0033433
Rothschild, S I; Tschan, M P; Federzoni, E A; Jaggi, R; Fey, M F; Gugger, M; Gautschi, O (2012). MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma. Oncogene, 31(38), pp. 4221-32. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2011.578
Rothschild, Sacha I; Tschan, Mario P; Jaggi, Rolf; Fey, Martin F; Gugger, Mathias; Gautschi, Oliver (2012). MicroRNA-381 Represses ID1 and is Deregulated in Lung Adenocarcinoma. Journal of thoracic oncology, 7(7), pp. 1069-77. Hagerstown, Md.: Wolters Kluwer Health/Lippincott Williams & Wilkins 10.1097/JTO.0b013e31824fe976
Federzoni, Elena A; Valk, Peter J M; Torbett, Bruce E; Haferlach, Torsten; Löwenberg, Bob; Fey, Martin F; Tschan, Mario P (2012). PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells. Blood, 119(21), pp. 4963-70. Washington, D.C.: American Society of Hematology 10.1182/blood-2011-09-378117
Humbert, Magali; Mueller, Chantal; Fey, Martin F; Tschan, Mario P (2012). Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells. Leukemia research, 36(12), pp. 1552-6. Amsterdam: Elsevier 10.1016/j.leukres.2012.08.024
Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A; Zhang, Xiao Yu Cindy; Dickman, Christopher T D; Fulton, Debra L; Lim, Jonathan S; Schnabl, Jake M; Ramos, Oscar H P; Vasseur-Cognet, Mireille; de Leeuw, Charles N; Simpson, Elizabeth M; Ryffel, Gerhart U; Lam, Eric W-F; Kist, Ralf; Wilson, Miranda S C; Marco-Ferreres, Raquel; ... (2012). The transcription factor encyclopedia. Genome biology, 13(3), R24. London: BioMed Central Ltd. 10.1186/gb-2012-13-3-r24
Rothschild, Sacha I; Kappeler, Andreas; Ratschiller, Daniel; Betticher, Daniel C; Tschan, Mario P; Gugger, Mathias; Gautschi, Oliver (2011). The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer. Lung cancer, 71(3), pp. 306-11. Amsterdam: Elsevier 10.1016/j.lungcan.2010.06.018
Batliner, Jasmin; Mancarelli, Maria Michela; Jenal, Mathias; Reddy, Venkateshwar A; Fey, Martin F; Torbett, Bruce E; Tschan, Mario P (2011). CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation. Molecular immunology, 48(4), pp. 714-9. Amsterdam: Elsevier 10.1016/j.molimm.2010.10.016
Humbert, Magali; Halter, Veronika; Shan, Deborah; Laedrach, Judith; Leibundgut, Elisabeth Oppliger; Baerlocher, Gabriela M; Tobler, Andreas; Fey, Martin F; Tschan, Mario P (2011). Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Leukemia research, 35(7), pp. 909-13. Amsterdam: Elsevier 10.1016/j.leukres.2011.03.010
Tschan, M P; Simon, H-U (2010). The role of autophagy in anticancer therapy: promises and uncertainties. Journal of internal medicine, 268(5), pp. 410-8. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2796.2010.02266.x
Schneider-Jakob, S; Corazza, N; Badmann, A; Sidler, D; Stuber-Roos, R; Keogh, A; Frese, S; Tschan, M; Brunner, T (2010). Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid. Cell death & disease, 1(e86), e86. London: Nature Publishing Group 10.1038/cddis.2010.66
Tschan, Mario P; Shan, Deborah; Laedrach, Judith; Eyholzer, Marianne; Leibundgut, Elisabeth Oppliger; Baerlocher, Gabriela M; Tobler, Andreas; Stroka, Deborah; Fey, Martin F (2010). NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leukemia research, 34(3), pp. 393-8. Amsterdam: Elsevier 10.1016/j.leukres.2009.08.037
Jenal, M; Batliner, J; Reddy, V A; Haferlach, T; Tobler, A; Fey, M F; Torbett, B E; Tschan, M P (2010). The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1. Leukemia, 24(5), pp. 1073-6. Basingstoke: Nature Publishing Group 10.1038/leu.2010.26
Britschgi, Adrian; Simon, Hans-Uwe; Tobler, Andreas; Fey, Martin F; Tschan, Mario P (2010). Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. British journal of haematology, 149(1), pp. 55-64. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2009.08040.x
Jenal, Mathias; Britschgi, Christian; Fey, Martin F; Tschan, Mario P (2010). Inactivation of the hypermethylated in cancer 1 tumour suppressor--not just a question of promoter hypermethylation? Swiss medical weekly, 140, w13106. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2011.13106
Van Rechem, C.; Rood, B. R.; Touka, M.; Pinte, S.; Jenal, Mathias; Guerardel, C.; Ramsey, K.; Monte, D.; Begue, A.; Tschan, Mario; Stephan, D. A.; Leprince, D. (2009). Scavenger Chemokine (CXC Motif) Receptor 7 (CXCR7) Is a Direct Target Gene of HIC1 (Hypermethylated in Cancer 1). Journal of biological chemistry, 284(31), pp. 20927-20935. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M109.022350
Wampfler, Julian; Tschan, Mario P; Shan, Deborah; Laemmle, Alexander; Leibundgut, Elisabeth O; Baerlocher, Gabriela M; Stroka, Deborah; Fey, Martin F; Britschgi, Christian (2009). SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells. British journal of haematology, 146(3), pp. 337-41. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2009.07749.x
Jenal, Mathias; Trinh, Emmanuelle; Britschgi, Christian; Britschgi, Adrian; Roh, Vincent; Vorburger, Stephan A; Tobler, Andreas; Leprince, Dominique; Fey, Martin F; Helin, Kristian; Tschan, Mario P (2009). The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Molecular cancer research, 7(6), pp. 916-22. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-08-0359
Tschan, M P; Reddy, V A; Ress, A; Arvidsson, G; Fey, M F; Torbett, B E (2008). PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity. Oncogene, 27(24), pp. 3489-93. Basingstoke, UK: Nature Publishing Group 10.1038/sj.onc.1211004
Blancafort, P.; Tschan, Mario; Bergquist, S.; Guthy, D.; Brachat, A.; Sheeter, D. A.; Torbett, B. E.; Erdmann, D.; Barbas, C. F. (2008). Modulation of drug resistance by artificial transcription factors. Molecular cancer therapeutics, 7(3), pp. 688-697. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-07-0381
Fang, J.; Menon, M.; Zhang, D.; Torbett, B.; Oxburgh, L.; Tschan, Mario; Houde, E.; Wojchowski, D. M. (2008). Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2. Blood, 112(3), pp. 886-890. American Society of Hematology 10.1182/blood-2008-02-138909
Britschgi, Christian; Jenal, Mathias; Rizzi, Mattia; Mueller, Beatrice U; Torbett, Bruce E; Andres, Anne-Catherine; Tobler, Andreas; Fey, Martin F; Tschan, Mario P (2008). HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation. British journal of haematology, 141(2), pp. 179-87. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2008.06992.x
Tschan, M P; Gullberg, U; Shan, D; Torbett, B E; Fey, M F; Tobler, A (2007). The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Leukemia, 22(5), pp. 1087-1090. Basingstoke: Nature Publishing Group 10.1038/sj.leu.2405018
Swan, C H; Bühler, B; Steinberger, P; Tschan, Mario; Barbas, C F; Torbett, B E (2007). T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery. Gene therapy, 14(7), p. 626. Nature Publishing Group 10.1038/sj.gt.3302902
Tschan, Mario; Fischer, K. M.; Fung, V. S.; Pirnia Borner, Farzaneh; Borner, Markus; Fey, Martin; Tobler, Andreas; Torbett, B. E. (2003). Alternative Splicing of the Human Cyclin D-binding Myb-like Protein (hDMP1) Yields a Truncated Protein Isoform That Alters Macrophage Differentiation Patterns. Journal of biological chemistry, 278(44), pp. 42750-42760. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M307067200
Novak, Urban; Grob, T. J.; Baskaynak, G.; Peters, U. R.; Aebi, Stefan; Zwahlen, D.; Tschan, Mario; Kreuzer, K.-A.; Oppliger Leibundgut, Elisabeth; Cajot, J.-F.; Tobler, Andreas; Fey, Martin (2001). Overexpression of the p73 gene is a novel finding in high-risk B-cell chronic lymphocytic leukemia. Annals of oncology, 12(7), pp. 981-986. Oxford University Press 10.1023/A:1011153206003
Tschan, Mario; Grob, Tobias J.; Peters, Uwe R.; Laurenzi, Vincenzo De; Huegli, B.; Kreuzer, K.-A.; Schmidt, C.A.; Melino, Gerry; Fey, Martin F.; Tobler, Andreas; Cajot, Jean-François (2000). Enhanced p73 Expression during Differentiation and Complex p73 Isoforms in Myeloid Leukemia. Biochemical and biophysical research communications, 277(1), pp. 62-65. Academic Press 10.1006/bbrc.2000.3627
Zwahlen, Daniel; Tschan, Mario; Grob, Tobias J.; Peters, Uwe R.; Fink, Daniel; Haenggi, Willy; Altermatt, Hans J.; Cajot, Jean-François; Tobler, Andreas; Fey, Martin F.; Aebi, Stefan (2000). Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours. International journal of cancer, 88(1), pp. 66-70. Wiley-Blackwell 10.1002/1097-0215(20001001)88:1<66::AID-IJC10>3.0.CO;2-Y
Tschan, Mario; Peters, U. R.; Cajot, J. F.; Betticher, D. C.; Fey, M. F.; Tobler, A. (1999). The cyclin-dependent kinase inhibitors p18INK4c and p19INK4d are highly expressed in CD34+ progenitor and acute myeloid leukaemic cells but not in normal differentiated myeloid cells. British journal of haematology, 106(3), pp. 644-651. Wiley-Blackwell 10.1046/j.1365-2141.1999.01617.x
Peters, Uwe R; Hasse, Urs; Oppliger Leibundgut, Elisabeth; Tschan, Mario; Ong, S Tiong; Rassool, Feyruz V; Borisch, Bettina; Tobler, Andreas; Fey, Martin (1999). Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia. Oncogene, 18(1), pp. 79-85. Nature Publishing Group 10.1038/sj.onc.1202256
