Support of hepatic regeneration by trophic factors from liver-derived mesenchymal stromal/stem cells

Fouraschen, Suomi M G; Hall, Sean; de Jonge, Jeroen; van der Laan, Luc J W (2014). Support of hepatic regeneration by trophic factors from liver-derived mesenchymal stromal/stem cells. Methods in molecular biology, 1213, pp. 89-104. Humana Press 10.1007/978-1-4939-1453-1_9

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Mesenchymal stromal/stem cells (MSCs) have multilineage differentiation potential and as such are known to promote regeneration in response to tissue injury. However, accumulating evidence indicates that the regenerative capacity of MSCs is not via transdifferentiation but mediated by their production of trophic and other factors that promote endogenous regeneration pathways of the tissue cells. In this chapter, we provide a detailed description on how to obtain trophic factors secreted by cultured MSCs and how they can be used in small animal models. More specific, in vivo models to study the paracrine effects of MSCs on regeneration of the liver after surgical resection and/or ischemia and reperfusion injury are described.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery

UniBE Contributor:

Hall, Sean

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1064-3745

Publisher:

Humana Press

Language:

English

Submitter:

Thomas Michael Marti

Date Deposited:

16 Mar 2015 12:53

Last Modified:

12 Nov 2015 09:42

Publisher DOI:

10.1007/978-1-4939-1453-1_9

PubMed ID:

25173377

BORIS DOI:

10.7892/boris.64711

URI:

https://boris.unibe.ch/id/eprint/64711

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