Phosphate disorders: hyperphosphatemia or pseudohyperphosphatemia?

Aeberhard, Nicole; Schild, Christof; Rodondi, Nicolas; Roten, Christine; Tänzler, Kristina (2014). Phosphate disorders: hyperphosphatemia or pseudohyperphosphatemia? Praxis - schweizerische Rundschau für Medizin, 103(20), pp. 1203-1206. Huber 10.1024/1661-8157/a001792

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We report the case of a 79 year old woman presenting with progressive confusion and drowsiness. Renal insufficiency with hyperkalemia as well as hypercalcemia and severe hyperphosphatemia were diagnosed. Renal insufficiency improved with treatment. However, hyperphosphatemia persisted without apparent explanation. We discuss possible causes of hyper- and pseudohyperphosphatemia. Specifically, phosphate analysis may be disturbed by the paraproteins in patients with multiple myeloma, resulting in pseudohyperphosphatemia. We review the standard laboratory phosphate measurement and the mechanisms of interference with paraproteins.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Schild, Christof; Rodondi, Nicolas; Roten, Christine and Tänzler, Kristina

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-8157

Publisher:

Huber

Language:

German

Submitter:

Patricia Rajaonina

Date Deposited:

16 Apr 2015 09:42

Last Modified:

09 Nov 2015 10:48

Publisher DOI:

10.1024/1661-8157/a001792

PubMed ID:

25270750

Uncontrolled Keywords:

Hyperphosphatämie, Pseudohyperphosphatämie, Multiples Myelom, Paraproteinämie

BORIS DOI:

10.7892/boris.65202

URI:

https://boris.unibe.ch/id/eprint/65202

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