To sense or not to sense viral RNA--essentials of coronavirus innate immune evasion.

Kindler, E; Thiel, Volker Earl (2014). To sense or not to sense viral RNA--essentials of coronavirus innate immune evasion. Current opinion in microbiology, 20, pp. 69-75. Elsevier 10.1016/j.mib.2014.05.005

[img] Text
1-s2.0-S1369527414000526-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (780kB) | Request a copy

An essential function of innate immunity is to distinguish self from non-self and receptors have evolved to specifically recognize viral components and initiate the expression of antiviral proteins to restrict viral replication. Coronaviruses are RNA viruses that replicate in the host cytoplasm and evade innate immune sensing in most cell types, either passively by hiding their viral signatures and limiting exposure to sensors or actively, by encoding viral antagonists to counteract the effects of interferons. Since many cytoplasmic viruses exploit similar mechanisms of innate immune evasion, mechanistic insight into the direct interplay between viral RNA, viral RNA-processing enzymes, cellular sensors and antiviral proteins will be highly relevant to develop novel antiviral targets and to restrict important animal and human infections.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Thiel, Volker Earl

Subjects:

600 Technology > 630 Agriculture

ISSN:

1369-5274

Publisher:

Elsevier

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

09 Apr 2015 11:42

Last Modified:

15 Oct 2015 10:52

Publisher DOI:

10.1016/j.mib.2014.05.005

PubMed ID:

24908561

BORIS DOI:

10.7892/boris.66678

URI:

https://boris.unibe.ch/id/eprint/66678

Actions (login required)

Edit item Edit item
Provide Feedback