Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances

Mani, Jan; Desy, Silvia Franziska; Niemann, Moritz; Chanfon, Astrid; Oeljeklaus, Silke; Pusnik, Mascha; Schmidt, Oliver; Gerbeth, Carolin; Meisinger, Chris; Warscheid, Bettina; Schneider, André (2015). Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nature communications, 6(6646), p. 6646. Nature Publishing Group 10.1038/ncomms7646

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Mitochondrial protein import is essential for all eukaryotes and mediated by hetero-oligomeric protein translocases thought to be conserved within all eukaryotes. We have identified and analysed the function and architecture of the non-conventional outer membrane (OM) protein translocase in the early diverging eukaryote Trypanosoma brucei. It consists of six subunits that show no obvious homology to translocase components of other species. Two subunits are import receptors that have a unique topology and unique protein domains and thus evolved independently of the prototype receptors ​Tom20 and ​Tom70. Our study suggests that protein import receptors were recruited to the core of the OM translocase after the divergence of the major eukaryotic supergroups. Moreover, it links the evolutionary history of mitochondrial protein import receptors to the origin of the eukaryotic supergroups.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Mani, Jan; Desy, Silvia Franziska; Niemann, Moritz; Chanfon, Astrid; Pusnik, Mascha and Schneider, André

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

2041-1723

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

22 Apr 2015 15:26

Last Modified:

26 Jun 2016 02:01

Publisher DOI:

10.1038/ncomms7646

BORIS DOI:

10.7892/boris.67011

URI:

https://boris.unibe.ch/id/eprint/67011

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