Hapfelmeier, Siegfried; Hardt, Wolf-Dietrich (2005). A mouse model for S. typhimurium-induced enterocolitis. Trends in microbiology, 13(10), pp. 497-503. Elsevier Current Trends 10.1016/j.tim.2005.08.008
Full text not available from this repository.Salmonella typhimurium has emerged as a model pathogen that manipulates host cells in a complex fashion, thus causing disease. In humans, S. typhimurium causes acute intestinal inflammation. Intriguingly, type III secreted virulence proteins have a central role in this process. At the cellular level, the functions of these factors are well characterized; at present, animal models are required for elucidating how these factors trigger inflammatory disease in vivo. Calf infection models have been employed successfully and, recently, a mouse model was identified: in streptomycin-pretreated mice, S. typhimurium causes acute colitis. This mouse model provides a new avenue for research into acute intestinal inflammation because it enables the manipulation and dissection of both the bacterial and host contributions to the disease in unsurpassed detail.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research |
UniBE Contributor: |
Hapfelmeier, Siegfried Hektor |
ISSN: |
0966-842X |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Siegfried Hektor Hapfelmeier-Balmer |
Date Deposited: |
04 May 2015 14:44 |
Last Modified: |
05 Dec 2022 14:46 |
Publisher DOI: |
10.1016/j.tim.2005.08.008 |
PubMed ID: |
16140013 |
Additional Information: |
Notes: papers3://publication/uuid/E2001E53-A9CF-456B-B7B4-AF7EB183F375 |
URI: |
https://boris.unibe.ch/id/eprint/67832 |
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