A mouse model for S. typhimurium-induced enterocolitis.

Hapfelmeier, Siegfried; Hardt, Wolf-Dietrich (2005). A mouse model for S. typhimurium-induced enterocolitis. Trends in microbiology, 13(10), pp. 497-503. Elsevier Current Trends 10.1016/j.tim.2005.08.008

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Salmonella typhimurium has emerged as a model pathogen that manipulates host cells in a complex fashion, thus causing disease. In humans, S. typhimurium causes acute intestinal inflammation. Intriguingly, type III secreted virulence proteins have a central role in this process. At the cellular level, the functions of these factors are well characterized; at present, animal models are required for elucidating how these factors trigger inflammatory disease in vivo. Calf infection models have been employed successfully and, recently, a mouse model was identified: in streptomycin-pretreated mice, S. typhimurium causes acute colitis. This mouse model provides a new avenue for research into acute intestinal inflammation because it enables the manipulation and dissection of both the bacterial and host contributions to the disease in unsurpassed detail.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research

UniBE Contributor:

Hapfelmeier, Siegfried Hektor

ISSN:

0966-842X

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Siegfried Hektor Hapfelmeier-Balmer

Date Deposited:

04 May 2015 14:44

Last Modified:

26 Jun 2016 02:01

Publisher DOI:

10.1016/j.tim.2005.08.008

PubMed ID:

16140013

Additional Information:

Notes: papers3://publication/uuid/E2001E53-A9CF-456B-B7B4-AF7EB183F375 Custom 1: Review Date: 2005

URI:

https://boris.unibe.ch/id/eprint/67832

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