Of mice, macaques and men: scaling of virus dynamics and immune responses

Althaus, Christian L (2015). Of mice, macaques and men: scaling of virus dynamics and immune responses. Frontiers in Microbiology, 6, p. 355. Frontiers 10.3389/fmicb.2015.00355

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In this Opinion piece, I argue that the dynamics of viruses and the cellular immune response depend on the body size of the host. I use allometric scaling theory to interpret observed quantitative differences in the infection dynamics of lymphocytic choriomeningitis virus (LCMV) in mice (Mus musculus), simian immunodeficiency virus (SIV) in rhesus macaques (Macaca mulatta) and human immunodeficiency virus (HIV) in humans.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Althaus, Christian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1664-302X

Publisher:

Frontiers

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

19 May 2015 14:06

Last Modified:

20 Sep 2017 09:55

Publisher DOI:

10.3389/fmicb.2015.00355

PubMed ID:

25954270

Uncontrolled Keywords:

allometric scaling, viral dynamics, viral replication, immune escape, cellular immune response, mice, macaques, humans

BORIS DOI:

10.7892/boris.68430

URI:

https://boris.unibe.ch/id/eprint/68430

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