Transition metal ligands as novel DNA-base substitutes

Brotschi, C.; Leumann, Christian (2003). Transition metal ligands as novel DNA-base substitutes. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1195-1197. Taylor & Francis 10.1081/NCN-120022834

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The base modified nucleoside dBP, carrying a non-hydrogen-bonding non-shape complementary base was incorporated into oligonucleotides (Brotschi, C.; Haberli, A.; Leumann C.J. Angew. Chem. Int. Ed. 2001, 40, 3012-3014). This base was designed to coordinate transition metal ions into well defined positions within a DNA double helix. Melting experiments revealed that the stability of a dBP:dBP base couple in a DNA duplex is similar to a dG:dC base pair even in the absence of transition metal ions. In the presence of transition metal ions, melting experiments revealed a decrease in duplex stability which is on a similar order for all metal ions (Mn2+, Cu2+, Zn2+, Ni2+) tested

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1525-7770

Publisher:

Taylor & Francis

Language:

English

Submitter:

Christian Leumann

Date Deposited:

19 May 2015 08:34

Last Modified:

19 May 2015 08:34

Publisher DOI:

10.1081/NCN-120022834

PubMed ID:

14565378

Additional Information:

Notes: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland brotschi@iocunibechFAU - Brotschi, Christine

Uncontrolled Keywords:

base base modified Base Pairing Base Sequence BASE-PAIR Cations,Divalent chemical synthesis chemistry Deoxyribonucleotides DNA double duplex DUPLEX STABILITY DUPLEXES helix Ligands metal Metals modified Nucleic Acid Conformation nucleoside OLIGODEOXYRIBONUCLEOTIDES oligonucleotide Oligonucleotides stability

BORIS DOI:

10.7892/boris.68571

URI:

https://boris.unibe.ch/id/eprint/68571

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