Brotschi, C.; Leumann, Christian (2003). Transition metal ligands as novel DNA-base substitutes. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1195-1197. Taylor & Francis 10.1081/NCN-120022834
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The base modified nucleoside dBP, carrying a non-hydrogen-bonding non-shape complementary base was incorporated into oligonucleotides (Brotschi, C.; Haberli, A.; Leumann C.J. Angew. Chem. Int. Ed. 2001, 40, 3012-3014). This base was designed to coordinate transition metal ions into well defined positions within a DNA double helix. Melting experiments revealed that the stability of a dBP:dBP base couple in a DNA duplex is similar to a dG:dC base pair even in the absence of transition metal ions. In the presence of transition metal ions, melting experiments revealed a decrease in duplex stability which is on a similar order for all metal ions (Mn2+, Cu2+, Zn2+, Ni2+) tested
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1525-7770 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 08:34 |
Last Modified: |
05 Dec 2022 14:46 |
Publisher DOI: |
10.1081/NCN-120022834 |
PubMed ID: |
14565378 |
Additional Information: |
Notes: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland brotschi@iocunibechFAU - Brotschi, Christine |
Uncontrolled Keywords: |
base base modified Base Pairing Base Sequence BASE-PAIR Cations,Divalent chemical synthesis chemistry Deoxyribonucleotides DNA double duplex DUPLEX STABILITY DUPLEXES helix Ligands metal Metals modified Nucleic Acid Conformation nucleoside OLIGODEOXYRIBONUCLEOTIDES oligonucleotide Oligonucleotides stability |
BORIS DOI: |
10.7892/boris.68571 |
URI: |
https://boris.unibe.ch/id/eprint/68571 |
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