Petitprez, Séverine; Zmoos, Anne-Flore; Ogrodnik, Jakob; Balse, Elise; Raad, Nour; El-Haou, Said; Albesa, Maxime; Bittihn, Philip; Luther, Stefan; Lehnart, Stephan E; Hatem, Stéphane N; Coulombe, Alain; Abriel, Hugues (2011). SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circulation research, 108(3), pp. 294-304. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.110.228312
Full text not available from this repository.The cardiac sodium channel Na(v)1.5 plays a key role in excitability and conduction. The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex. As dystrophin is absent at the intercalated discs, Na(v)1.5 could potentially interact with other, yet unknown, proteins at this site.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology |
UniBE Contributor: |
Petitprez, Séverine, Ogrodnik, Jakob, Albesa, Maxime, Abriel, Hugues |
ISSN: |
0009-7330 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:20 |
Last Modified: |
05 Dec 2022 14:05 |
Publisher DOI: |
10.1161/CIRCRESAHA.110.228312 |
PubMed ID: |
21164104 |
Web of Science ID: |
000286930500006 |
URI: |
https://boris.unibe.ch/id/eprint/6859 (FactScience: 211898) |
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