SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

Petitprez, Séverine; Zmoos, Anne-Flore; Ogrodnik, Jakob; Balse, Elise; Raad, Nour; El-Haou, Said; Albesa, Maxime; Bittihn, Philip; Luther, Stefan; Lehnart, Stephan E; Hatem, Stéphane N; Coulombe, Alain; Abriel, Hugues (2011). SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circulation research, 108(3), pp. 294-304. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.110.228312

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The cardiac sodium channel Na(v)1.5 plays a key role in excitability and conduction. The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex. As dystrophin is absent at the intercalated discs, Na(v)1.5 could potentially interact with other, yet unknown, proteins at this site.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Petitprez, Séverine; Ogrodnik, Jakob; Albesa, Maxime and Abriel, Hugues

ISSN:

0009-7330

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:20

Last Modified:

17 Mar 2015 19:27

Publisher DOI:

10.1161/CIRCRESAHA.110.228312

PubMed ID:

21164104

Web of Science ID:

000286930500006

URI:

https://boris.unibe.ch/id/eprint/6859 (FactScience: 211898)

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