Sharma, Rahul; Jost, Daniel; Kind, Jop; Gómez-Saldivar, Georgina; van Steensel, Bas; Askjaer, Peter; Vaillant, Cédric; Meister, Pierre (2014). Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans. Genes & development, 28(23), pp. 2591-2596. Cold Spring Harbor Laboratory Press 10.1101/gad.248864.114
|
Text
Sharma_GnD_2014.pdf - Published Version Available under License Publisher holds Copyright. Download (1MB) | Preview |
The adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Sharma, Rahul, Meister, Pierre |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0890-9369 |
Publisher: |
Cold Spring Harbor Laboratory Press |
Language: |
English |
Submitter: |
Pierre Meister |
Date Deposited: |
07 May 2015 10:56 |
Last Modified: |
05 Dec 2022 14:47 |
Publisher DOI: |
10.1101/gad.248864.114 |
PubMed ID: |
25452271 |
BORIS DOI: |
10.7892/boris.68766 |
URI: |
https://boris.unibe.ch/id/eprint/68766 |
Actions (login required)
 |
Edit item |