Quantitative analysis of imprint shape and its relation to mechanical properties measured by microindentation in bone

Schwiedrzik, Johann Jakob; Zysset, Philippe (2015). Quantitative analysis of imprint shape and its relation to mechanical properties measured by microindentation in bone. Journal of biomechanics, 48(2), 210 - 216. Elsevier 10.1016/j.jbiomech.2014.12.001

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Microindentation in bone is a micromechanical testing technique routinely used to extract material properties related to bone quality. As the analysis of microindentation data is based on assumptions about the contact between sample and surface, the aim of this study was to quantify the topological variability of indentations in bone and examine its relationship with mechanical properties. Indentations were performed in dry human and ovine bone in axial and transverse directions and their topology was measured by atomic force microscopy. Statistical shape modeling of the residual imprint allowed to define a mean shape and to describe the variability in terms of 21 principal components related to imprint depth, surface curvature and roughness. The indentation profile of bone was found to be highly consistent and free of any pile up while differing mostly by depth between species and direction. A few of the topological parameters, in particular depth, showed significant but rather weak and inconsistent correlations to variations in mechanical properties. The mechanical response of bone as well as the residual imprint shape was highly consistent within each category. We could thus verify that bone is rather homogeneous in its micromechanical properties and that indentation results are not strongly influenced by small deviations from an ideally flat surface.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Schwiedrzik, Johann Jakob and Zysset, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0021-9290

Publisher:

Elsevier

Language:

English

Submitter:

Johann Jakob Schwiedrzik

Date Deposited:

04 Jun 2015 08:13

Last Modified:

26 Nov 2015 14:18

Publisher DOI:

10.1016/j.jbiomech.2014.12.001

PubMed ID:

25527891

Uncontrolled Keywords:

Bone; Microindentation; Residual imprint; Atomic force microscopy; Statistical shape modeling

BORIS DOI:

10.7892/boris.69215

URI:

https://boris.unibe.ch/id/eprint/69215

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