Morard, Isabelle; Clément, Sophie; Calmy, Alexandra; Mangia, Alessandra; Cerny, Andrea; De Gottardi, Andrea; Gorgievski, Meri; Heim, Markus; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; Semela, David; Pascarella, Stéphanie; Bochud, Pierre-Yves; Negro, Franco (2014). Clinical significance of the CCR5delta32 allele in hepatitis C. PLoS ONE, 9(9), e106424. Public Library of Science 10.1371/journal.pone.0106424
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BACKGROUND
The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection.
METHODS
CCR5 and HCV-related phenotypes were analysed in 1,290 chronically infected patients and 160 patients with spontaneous clearance.
RESULTS
Carriage of the CCR5delta32 allele was observed in 11% of spontaneous clearers compared to 17% of chronically infected patients (OR = 0.59, 95% CI interval 0.35-0.99, P = 0.047). Carriage of this allele also tended to be observed more frequently among patients with liver inflammation (19%) compared to those without inflammation (15%, OR = 1.38, 95% CI interval 0.99-1.95, P = 0.06). The CCR5delta32 was not associated with sustained virological response (P = 0.6), fibrosis stage (P = 0.8), or fibrosis progression rate (P = 0.4).
CONCLUSIONS
The CCR5delta32 allele appears to be associated with a decreased rate of spontaneous HCV eradication, but not with hepatitis progression or response to antiviral therapy.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
De Gottardi, Andrea, Gorgievski, Meri |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Meri Gorgievski |
Date Deposited: |
01 Jun 2015 09:59 |
Last Modified: |
05 Dec 2022 14:47 |
Publisher DOI: |
10.1371/journal.pone.0106424 |
PubMed ID: |
25191700 |
BORIS DOI: |
10.7892/boris.69230 |
URI: |
https://boris.unibe.ch/id/eprint/69230 |
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