DNA-Grafted Supramolecular Polymers: Helical Ribbon Structures Formed by Self-Assembly of Pyrene-DNA Chimeric Oligomers

Vyborna, Yuliia; Vybornyi, Mykhailo; Rudnev, Alexander V.; Häner, Robert (2015). DNA-Grafted Supramolecular Polymers: Helical Ribbon Structures Formed by Self-Assembly of Pyrene-DNA Chimeric Oligomers. Angewandte Chemie (International ed.), 54(27), pp. 7934-7938. Wiley-VCH 10.1002/anie.201502066

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The controlled arraying of DNA strands on adaptive polymeric platforms remains a challenge. Here, the noncovalent synthesis of DNA-grafted supramolecular polymers from short chimeric oligomers is presented. The oligomers are composed of an oligopyrenotide strand attached to the 5′-end of an oligodeoxynucleotide. The supramolecular polymerization of these oligomers in an aqueous medium leads to the formation of one-dimensional (1D) helical ribbon structures. Atomic force and transmission electron microscopy show rod-like polymers of several hundred nanometers in length. DNA-grafted polymers of the type described herein will serve as models for the development of structurally and functionally diverse supramolecular platforms with applications in materials science and diagnostics.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Vyborna, Yuliia; Vybornyi, Mykhailo; Rudnev, Alexander and Häner, Robert

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1433-7851

Publisher:

Wiley-VCH

Funders:

[4] Swiss National Science Foundation
[UNSPECIFIED] FP7 Project ACMOL

Language:

English

Submitter:

Robert Häner

Date Deposited:

11 Jun 2015 13:46

Last Modified:

25 Jun 2015 08:04

Publisher DOI:

10.1002/anie.201502066

Related URLs:

PubMed ID:

25960306

BORIS DOI:

10.7892/boris.69403

URI:

https://boris.unibe.ch/id/eprint/69403

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