Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria

Gentinetta, Thomas; Pecaric-Petkovic, Tatjana; Wan, Daniel; Falcone, Franco H; Dahinden, Clemens A; Pichler, Werner J; Hausmann, Oliver V (2011). Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. Journal of allergy and clinical immunology, 128(6), 1227-1234.e5. St. Louis, Mo.: Mosby 10.1016/j.jaci.2011.07.021

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The in vivo autologous serum skin test (ASST) is the diagnostic gold standard to detect autoantibodies against FcεRI or IgE itself, as well as other autoreactive serum components, in patients with chronic spontaneous urticaria (CU). Coincubation of patient sera with donor basophils and measuring their degranulation in vitro could be a safe alternative but has shown inconsistent results.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology (discontinued)
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Dahinden, Clemens A. and Pichler, Werner Joseph

ISSN:

0091-6749

Publisher:

Mosby

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

17 Mar 2015 19:28

Publisher DOI:

10.1016/j.jaci.2011.07.021

PubMed ID:

21855127

Web of Science ID:

000298342700011

URI:

https://boris.unibe.ch/id/eprint/6972 (FactScience: 212106)

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