Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein

Eggel, A; Buschor, P; Baumann, M J; Amstutz, P; Stadler, B M; Vogel, M (2011). Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein. Allergy, 66(7), pp. 961-8. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02546.x

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Aggregation of the high-affinity IgE receptor (FcεRI) with the low-affinity IgG receptor (FcγRIIb) on basophils or mast cells has been shown to inhibit allergen-induced cell degranulation. Molecules cross-linking these two receptors might therefore be of interest for the treatment of allergic disorders. Here, we demonstrate the generation of a novel bispecific fusion protein efficiently aggregating FcεRI-bound IgE with FcγRIIb on the surface of basophils to prevent pro-inflammatory mediator release.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology (discontinued)

UniBE Contributor:

Eggel, Alexander; Buschor, Patrick; Stadler, Beda Martin and Vogel, Monique

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

06 Dec 2013 13:27

Publisher DOI:

10.1111/j.1398-9995.2011.02546.x

PubMed ID:

21272035

Web of Science ID:

000291220000021

URI:

https://boris.unibe.ch/id/eprint/6976 (FactScience: 212110)

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