Eggel, A; Buschor, P; Baumann, M J; Amstutz, P; Stadler, B M; Vogel, M (2011). Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein. Allergy, 66(7), pp. 961-8. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02546.x
Full text not available from this repository.Aggregation of the high-affinity IgE receptor (FcεRI) with the low-affinity IgG receptor (FcγRIIb) on basophils or mast cells has been shown to inhibit allergen-induced cell degranulation. Molecules cross-linking these two receptors might therefore be of interest for the treatment of allergic disorders. Here, we demonstrate the generation of a novel bispecific fusion protein efficiently aggregating FcεRI-bound IgE with FcγRIIb on the surface of basophils to prevent pro-inflammatory mediator release.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology [discontinued] |
UniBE Contributor: |
Eggel, Alexander, Buschor, Patrick, Stadler, Beda Martin, Vogel, Monique |
ISSN: |
0105-4538 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:21 |
Last Modified: |
05 Dec 2022 14:06 |
Publisher DOI: |
10.1111/j.1398-9995.2011.02546.x |
PubMed ID: |
21272035 |
Web of Science ID: |
000291220000021 |
URI: |
https://boris.unibe.ch/id/eprint/6976 (FactScience: 212110) |
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