Exercise-associated glucose metabolism in individuals with type 1 diabetes mellitus.

Bally, Lia; Laimer, Markus; Stettler, Christoph (2015). Exercise-associated glucose metabolism in individuals with type 1 diabetes mellitus. Current opinion in clinical nutrition and metabolic care, 18(4), pp. 428-433. Lippincott, Williams & Wilkins 10.1097/MCO.0000000000000185

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PURPOSE OF REVIEW The primary focus of this review is threefold: first, to summarize available knowledge on exercise-associated glucose metabolism in individuals with type 1 diabetes mellitus (T1DM); second, to elucidate physiological mechanisms predisposing to glycemic variations in patients in T1DM; and third, to describe novel approaches derived from physiological perceptions applicable to stabilize exercise-related glycemia in individuals with T1DM. RECENT FINDINGS Recent studies corroborate the concept that despite partial differences in counter-regulatory mechanisms individuals with T1DM do not fundamentally differ in their glucose response to exercise when compared with healthy individuals if studies are performed under standardized conditions with insulin and glucose levels held close to physiological ranges. Novel approaches derived from a better understanding of exercise-associated glucose metabolism (e.g., the concept of intermittent high-intensity exercise) may provide alternative ways to master the challenges imposed by exercise to individuals with T1DM. SUMMARY Exercise still imposes high demands on patients with T1DM and increases risks for hypoglycemia and hyperglycemia. Deeper insight into the associated metabolic pathways has revealed novel options to stabilize exercise-associated glucose levels in these patients.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bally, Lia; Laimer, Markus and Stettler, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1363-1950

Publisher:

Lippincott, Williams & Wilkins

Language:

English

Submitter:

Markus Laimer

Date Deposited:

03 Jul 2015 08:26

Last Modified:

01 Aug 2016 02:30

Publisher DOI:

10.1097/MCO.0000000000000185

PubMed ID:

26001653

BORIS DOI:

10.7892/boris.70057

URI:

https://boris.unibe.ch/id/eprint/70057

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