Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS

Ambach, Lars; Hernández Redondo, Ana; König, Stefan; Angerer, Verena; Schürch, Stefan; Weinmann, Wolfgang (2015). Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS. Bioanalysis, 7(9), pp. 1119-1136. Future Science 10.4155/bio.15.48

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BACKGROUND New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as 'bath salts' or 'research chemicals' and comprehensive bioanalytical methods are needed for their detection. METHODOLOGY We developed and validated a method using LC and MS/MS to quantify 56 NPS in blood and urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives and others. Instrumentation included a Synergi Polar-RP column (Phenomenex) and a 3200 QTrap mass spectrometer (AB Sciex). Run time was 20 min. CONCLUSION A novel method is presented for the unambiguous identification and quantification of 56 NPS in blood and urine samples in clinical and forensic cases, e.g., intoxications or driving under the influence of drugs.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology

UniBE Contributor:

Ambach, Lars; König, Stefan; Schürch, Stefan and Weinmann, Wolfgang

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
600 Technology > 610 Medicine & health

ISSN:

1757-6180

Publisher:

Future Science

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

08 Jul 2015 17:04

Last Modified:

22 Jan 2016 11:07

Publisher DOI:

10.4155/bio.15.48

PubMed ID:

26039809

URI:

https://boris.unibe.ch/id/eprint/70168

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