Ambach, Lars; Hernández Redondo, Ana; König, Stefan; Angerer, Verena; Schürch, Stefan; Weinmann, Wolfgang (2015). Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS. Bioanalysis, 7(9), pp. 1119-1136. Future Science 10.4155/bio.15.48
Full text not available from this repository.BACKGROUND
New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as 'bath salts' or 'research chemicals' and comprehensive bioanalytical methods are needed for their detection.
METHODOLOGY
We developed and validated a method using LC and MS/MS to quantify 56 NPS in blood and urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives and others. Instrumentation included a Synergi Polar-RP column (Phenomenex) and a 3200 QTrap mass spectrometer (AB Sciex). Run time was 20 min.
CONCLUSION
A novel method is presented for the unambiguous identification and quantification of 56 NPS in blood and urine samples in clinical and forensic cases, e.g., intoxications or driving under the influence of drugs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) 04 Faculty of Medicine > Service Sector > Institute of Legal Medicine 04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology |
UniBE Contributor: |
Ambach, Lars, König, Stefan (A), Schürch, Stefan, Weinmann, Wolfgang |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 600 Technology > 610 Medicine & health |
ISSN: |
1757-6180 |
Publisher: |
Future Science |
Language: |
English |
Submitter: |
Antoinette Angehrn |
Date Deposited: |
08 Jul 2015 17:04 |
Last Modified: |
29 Mar 2023 23:34 |
Publisher DOI: |
10.4155/bio.15.48 |
PubMed ID: |
26039809 |
URI: |
https://boris.unibe.ch/id/eprint/70168 |
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