Molecular and pathogenetic aspects of tumor budding in colorectal cancer.

Dawson, Heather; Lugli, Alessandro (2015). Molecular and pathogenetic aspects of tumor budding in colorectal cancer. Frontiers in medicine, 2(11), p. 11. Frontiers 10.3389/fmed.2015.00011

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In recent years, tumor budding in colorectal cancer has gained much attention as an indicator of lymph node metastasis, distant metastatic disease, local recurrence, worse overall and disease-free survival, and as an independent prognostic factor. Tumor buds, defined as the presence of single tumor cells or small clusters of up to five tumor cells at the peritumoral invasive front (peritumoral buds) or within the main tumor body (intratumoral buds), are thought to represent the morphological correlate of cancer cells having undergone epithelial-mesenchymal transition (EMT), an important mechanism for the progression of epithelial cancers. In contrast to their undisputed prognostic power and potential to influence clinical management, our current understanding of the biological background of tumor buds is less established. Most studies examining tumor buds have attempted to recapitulate findings of mechanistic EMT studies using immunohistochemical markers. The aim of this review is to provide a comprehensive summary of studies examining protein expression profiles of tumor buds and to illustrate the molecular pathways and crosstalk involved in their formation and maintenance.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology

UniBE Contributor:

Dawson, Heather and Lugli, Alessandro

ISSN:

2296-858X

Publisher:

Frontiers

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

13 Jul 2015 10:17

Last Modified:

15 Jan 2017 02:00

Publisher DOI:

10.3389/fmed.2015.00011

PubMed ID:

25806371

Uncontrolled Keywords:

EMT; colorectal cancer; immunohistochemistry; tumor budding; tumor microenvironment

BORIS DOI:

10.7892/boris.70186

URI:

https://boris.unibe.ch/id/eprint/70186

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