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Dawson, Heather; Bokhorst, John-Melle; Studer, Linda; Vieth, Michael; Oguz Erdogan, Ayse Selcen; Kus Öztürk, Sonay; Kirsch, Richard; Brockmoeller, Scarlett; Cathomas, Gieri; Buslei, Rolf; Fink, David; Roumet, Marie; Zlobec, Inti; van der Laak, Jeroen; Nagtegaal, Iris D; Lugli, Alessandro (2024). Lymph node metastases and recurrence in pT1 colorectal cancer: Prediction with the International Budding Consortium Score-A retrospective, multi-centric study. United European gastroenterology journal, 12(3), pp. 299-308. Wiley 10.1002/ueg2.12521
Brouwer, N P M; Khan, A; Bokhorst, J M; Ayatollahi, F; Hay, J; Ciompi, F; Simmer, F; Hugen, N; de Wilt, J H W; Berger, M D; Lugli, A; Zlobec, I; Edwards, J; Nagtegaal, I D (2024). The complexity of shapes; how the circularity of tumor nodules impacts prognosis in colorectal cancer. Modern pathology, 37(1), p. 100376. Elsevier 10.1016/j.modpat.2023.100376
Frei, Ana Leni; Oberson, Raphaël; Baumann, Elias; Perren, Aurel; Grobholz, Rainer; Lugli, Alessandro; Dawson, Heather; Abbet, Christian; Lertxundi, Ibai; Reinhard, Stefan; Mookhoek, Aart; Feichtinger, Johann; Sarro, Rossella; Gadient, Gallus; Dommann-Scherrer, Corina; Barizzi, Jessica; Berezowska, Sabina; Glatz, Katharina; Dertinger, Susanne; Banz, Yara; ... (2023). Pathologist computer-aided diagnostic scoring of tumor cell fraction: A Swiss national study. Modern pathology, 36(12), p. 100335. Springer Nature 10.1016/j.modpat.2023.100335
Haddad, Tariq Sami; van den Dobbelsteen, Luuk; Öztürk, Sonay K; Geene, Robin; Nijman, Isaäc J; Verrijp, Kiek; Jamieson, Nigel B; Wood, Colin; van Vliet, Shannon; Reuvers, Luuk; Achouiti, Soumia; Rutgers, Natasja; Brouwer, Nelleke; Simmer, Femke; Zlobec, Inti; Lugli, Alessandro; Nagtegaal, Iris D (2023). Pseudobudding: ruptured glands do not represent true tumor buds. The journal of pathology: clinical research, 261(1), pp. 19-27. Wiley 10.1002/path.6146
Swillens, Julie E M; Nagtegaal, Iris D; Engels, Sam; Lugli, Alessandro; Hermens, Rosella P M G; van der Laak, Jeroen A W M (2023). Pathologists' first opinions on barriers and facilitators of computational pathology adoption in oncological pathology: an international study. Oncogene, 42(38), pp. 2816-2827. Springer Nature 10.1038/s41388-023-02797-1
Willis, Joseph; Anders, Robert A; Torigoe, Toshihiko; Hirohashi, Yoshihiko; Bifulco, Carlo; Zlobec, Inti; Mlecnik, Bernhard; Demaria, Sandra; Choi, Won-Tak; Dundr, Pavel; Tatangelo, Fabiana; Di Mauro, Annabella; Baldin, Pamela; Bindea, Gabriela; Marliot, Florence; Haicheur, Nacilla; Fredriksen, Tessa; Kirilovsky, Amos; Buttard, Bénédicte; Vasaturo, Angela; ... (2023). Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore. Cancers, 15(16) MDPI AG 10.3390/cancers15164045
Khan, Amjad; Brouwer, Nelleke; Blank, Annika; Müller, Felix; Soldini, Davide; Noske, Aurelia; Gaus, Elisabeth; Brandt, Simone; Nagtegaal, Iris; Dawson, Heather; Thiran, Jean-Philippe; Perren, Aurel; Lugli, Alessandro; Zlobec, Inti (2023). Computer-Assisted Diagnosis of Lymph Node Metastases in Colorectal Cancers Using Transfer Learning With an Ensemble Model. Modern pathology, 36(5), p. 100118. Springer Nature 10.1016/j.modpat.2023.100118
Frei, Ana Leni; Khan, Amjad; Zens, Philipp; Lugli, Alessandro; Zlobec, Inti; Fischer, Andreas (28 April 2023). GammaFocus: An image augmentation method to focus model attention for classification. In: Medical Imaging with Deep Learning 2023.
Frei, Ana Leni; Khan, Amjad; Studer, Linda; Zens, Philipp; Lugli, Alessandro; Fischer, Andreas; Zlobec, Inti (28 April 2023). Local and global feature aggregation for accurate epithelial cell classification using graph attention mechanisms in histopathology images. In: Medical Imaging with deep Learning 2023.
Bokhorst, John-Melle; Nagtegaal, Iris D; Zlobec, Inti; Dawson, Heather; Sheahan, Kieran; Simmer, Femke; Kirsch, Richard; Vieth, Michael; Lugli, Alessandro; van der Laak, Jeroen; Ciompi, Francesco (2023). Semi-Supervised Learning to Automate Tumor Bud Detection in Cytokeratin-Stained Whole-Slide Images of Colorectal Cancer. Cancers, 15(7) MDPI AG 10.3390/cancers15072079
Mlecnik, Bernhard; Lugli, Alessandro; Bindea, Gabriela; Marliot, Florence; Bifulco, Carlo; Lee, Jiun-Kae Jack; Zlobec, Inti; Rau, Tilman T; Berger, Martin D; Nagtegaal, Iris D; Vink-Börger, Elisa; Hartmann, Arndt; Geppert, Carol I; Kolwelter, Julie; Merkel, Susanne; Grützmann, Robert; Van den Eynde, Marc; Jouret-Mourin, Anne; Kartheuser, Alex; Léonard, Daniel; ... (2023). Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer. Cancers, 15(2) MDPI AG 10.3390/cancers15020418
Noti, Luca; Galván, José; Dawson, Heather; Lugli, Alessandro; Kirsch, Richard; Assarzadegan, Naziheh; Messenger, David; Krebs, Philippe; Berger, Martin D; Zlobec, Inti (2022). A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer. BMC cancer, 22(1), p. 987. BioMed Central 10.1186/s12885-022-10048-x
Mlecnik, Bernhard; Torigoe, Toshihiko; Bindea, Gabriela; Popivanova, Boryana; Xu, Mingli; Fujita, Tomonobu; Hazama, Shoichi; Suzuki, Nobuaki; Nagano, Hiroaki; Okuno, Kiyotaka; Hirohashi, Yoshihiko; Furuhata, Tomohisa; Takemasa, Ichiro; Patel, Prabhudas; Vora, Hemangini; Shah, Birva; Patel, Jayendrakumar B; Rajvik, Kruti N; Pandya, Shashank J; Shukla, Shilin N; ... (2022). Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study. Cancers, 14(18) MDPI AG 10.3390/cancers14184346
Loughrey, Maurice B.; Webster, Fleur; Arends, Mark J.; Brown, Ian; Burgart, Lawrence J.; Cunningham, Chris; Flejou, Jean-Francois; Kakar, Sanjay; Kirsch, Richard; Kojima, Motohiro; Lugli, Alessandro; Rosty, Christophe; Sheahan, Kieran; West, Nicholas P.; Wilson, Richard H.; Nagtegaal, Iris D. (2022). Dataset for Pathology Reporting of Colorectal Cancer: Recommendations from the International Collaboration on Cancer Reporting (ICCR). Annals of surgery, 275(3), e549-e561. Wolters Kluwer 10.1097/SLA.0000000000005051
Müller, Felix; Lugli, Alessandro; Dawson, Heather (2022). Tumor budding in colorectal cancer—Information for clinical use and instructions for practical evaluation. Pathologe, 43(1), pp. 45-50. Springer-Medizin-Verlag 10.1007/s00292-021-01016-6
Nguyen, Huu-Giao; Lundström, Oxana; Blank, Annika; Dawson, Heather; Lugli, Alessandro; Anisimova, Maria; Zlobec, Inti (2022). Image-based assessment of extracellular mucin-to-tumor area predicts consensus molecular subtypes (CMS) in colorectal cancer. Modern pathology, 35(2), pp. 240-248. Springer Nature 10.1038/s41379-021-00894-8
Khan, Amjad; Janowczyk, Andrew; Müller, Felix; Blank, Annika; Nguyen, Huu Giao; Abbet, Christian; Studer, Linda; Lugli, Alessandro; Dawson, Heather; Thiran, Jean-Philippe; Zlobec, Inti (2022). Impact of scanner variability on lymph node segmentation in computational pathology. Journal of pathology informatics, 13(100127), p. 100127. Elsevier 10.1016/j.jpi.2022.100127
Zlobec, Inti; Bächli, Melanie; Galuppini, Francesca; Berger, Martin D.; Dawson, Heather E.; Nagtegaal, Iris D; Lugli, Alessandro (2021). Refining the ITBCC tumor budding scoring system with a "zero-budding" category in colorectal cancer. Virchows Archiv, 479(6), pp. 1085-1090. Springer 10.1007/s00428-021-03090-w
Haddad, Tariq Sami; Lugli, Alessandro; Aherne, Susan; Barresi, Valeria; Terris, Benoît; Bokhorst, John-Melle; Brockmoeller, Scarlet Fiona; Cuatrecasas, Miriam; Simmer, Femke; El-Zimaity, Hala; Fléjou, Jean-François; Gibbons, David; Cathomas, Gieri; Kirsch, Richard; Kuhlmann, Tine Plato; Langner, Cord; Loughrey, Maurice B; Riddell, Robert; Ristimäki, Ari; Kakar, Sanjay; ... (2021). Improving tumor budding reporting in colorectal cancer: a Delphi consensus study. Virchows Archiv, 479(3), pp. 459-469. Springer 10.1007/s00428-021-03059-9
Lugli, Alessandro; Carneiro, Fatima; Dawson, Heather; Fléjou, Jean-François; Kirsch, Richard; van der Post, Rachel; Vieth, Michael; Svrcek, Magali (2021). L’autopsie de Napoléon Bonaparte. Mise au point anatomo-pathologique pour le bicentenaire de la mort de Napoléon Ier sur l’île de Sainte-Hélène en 1821. Annales de pathologie, 41(4), pp. 381-386. Elsevier 10.1016/j.annpat.2021.04.004
Georges, Nadine DF; Oberli, Beatrice; Rau, Tilman; Galván, José; Nagtegaal, Iris D; Dawson, Heather; Blank, Annika; Kohler, Andreas; Lugli, Alessandro; Zlobec, Inti (2021). Tumour budding and CD8+ T-cells: "attackers" and "defenders" in rectal cancer with and without neoadjuvant chemoradiotherapy. Histopathology, 78(7), pp. 1009-1018. Wiley 10.1111/his.14319
Studer, Linda; Blank, Annika; Bokhorst, John-Melle; Nagtegaal, Iris D; Zlobec, Inti; Lugli, Alessandro; Fischer, Andreas; Dawson, Heather (2021). Taking Tumour Budding to the Next Frontier - a Post-ITBCC 2016 Review. Histopathology, 78(4), pp. 476-484. Wiley 10.1111/his.14267
Lugli, Alessandro; Zlobec, Inti; Berger, Martin D.; Kirsch, Richard; Nagtegaal, Iris D (2021). Tumour budding in solid cancers. Nature reviews. Clinical oncology, 18(2), pp. 101-115. Springer Nature 10.1038/s41571-020-0422-y
Nguyen, Huu-Giao; Blank, Annika; Dawson, Heather E.; Lugli, Alessandro; Zlobec, Inti (2021). Classification of colorectal tissue images from high throughput tissue microarrays by ensemble deep learning methods. Scientific reports, 11(1), p. 2371. Springer Nature 10.1038/s41598-021-81352-y
Burren, Sandra; Reche, Katharina; Blank, Annika; Galván, José A.; Dawson, Heather; Berger, Martin D.; Zlobec, Inti; Lugli, Alessandro (2021). RHAMM in liver metastases of stage IV colorectal cancer with mismatch-repair proficient status correlates with tumor budding, cytotoxic T-cells and PD-1/PD-L1. Pathology, research and practice, 223, p. 153486. Elsevier 10.1016/j.prp.2021.153486
Rhyner Agocs, Gaëlle; Assarzadegan, Naziheh; Kirsch, Richard; Dawson, Heather; Galván, José A.; Lugli, Alessandro; Zlobec, Inti; Berger, Martin D. (2021). LAG-3 Expression Predicts Outcome in Stage II Colon Cancer. Journal of personalized medicine, 11(8) MDPI 10.3390/jpm11080749
Lang-Schwarz, Corinna; Angeloni, Miriam; Agaimy, Abbas; Atreya, Raja; Becker, Christoph; Dregelies, Theresa; Danese, Silvio; Fléjou, Jean-François; Gaßler, Nikolaus; Grabsch, Heike I; Hartmann, Arndt; Kamarádová, Kateřina; Kühl, Anja A; Lauwers, Gregory Y; Lugli, Alessandro; Nagtegaal, Iris; Neurath, Markus F; Oberhuber, Georg; Peyrin-Biroulet, Laurent; Rath, Timo; ... (2021). Validation of the ‘Inflammatory Bowel Disease—Distribution, Chronicity, Activity [IBD-DCA] Score’ for Ulcerative Colitis and Crohn´s Disease. Journal of Crohn's & colitis, 15(10), pp. 1621-1630. Oxford University Press 10.1093/ecco-jcc/jjab055
Lugli, Alessandro; Carneiro, Fatima; Dawson, Heather; Fléjou, Jean-François; Kirsch, Richard; van der Post, Rachel S.; Vieth, Michael; Svrcek, Magali (2021). The gastric disease of Napoleon Bonaparte: brief report for the bicentenary of Napoleon’s death on St. Helena in 1821. Virchows Archiv, 479(5), pp. 1055-1060. Springer 10.1007/s00428-021-03061-1
Lang-Schwarz, Corinna; Agaimy, Abbas; Atreya, Raja; Becker, Christoph; Danese, Silvio; Fléjou, Jean-François; Gaßler, Nikolaus; Grabsch, Heike I.; Hartmann, Arndt; Kamarádová, Kateřina; Kühl, Anja A.; Lauwers, Gregory Y.; Lugli, Alessandro; Nagtegaal, Iris; Neurath, Markus F.; Oberhuber, Georg; Peyrin-Biroulet, Laurent; Rath, Timo; Riddell, Robert; Rubio, Carlos A.; ... (2021). Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn’s disease. Virchows Archiv, 478(3), pp. 581-594. Springer 10.1007/s00428-020-02982-7
Mlecnik, Bernhard; Bifulco, Carlo; Bindea, Gabriela; Marliot, Florence; Lugli, Alessandro; Lee, J Jack; Zlobec, Inti; Rau, Tilman T.; Berger, Martin D.; Nagtegaal, Iris D; Vink-Börger, Elisa; Hartmann, Arndt; Geppert, Carol; Kolwelter, Julie; Merkel, Susanne; Grützmann, Robert; Van den Eynde, Marc; Jouret-Mourin, Anne; Kartheuser, Alex; Léonard, Daniel; ... (2020). Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer. Journal of clinical oncology, 38(31), pp. 3638-3651. American Society of Clinical Oncology 10.1200/JCO.19.03205
Zlobec, Inti; Berger, Martin D.; Lugli, Alessandro (2020). Tumour budding and its clinical implications in gastrointestinal cancers. British journal of cancer, 123(5), pp. 700-708. Nature Publishing Group 10.1038/s41416-020-0954-z
Bokhorst, J. M.; Blank, A.; Lugli, A.; Zlobec, I.; Dawson, H.; Vieth, M.; Rijstenberg, L. L.; Brockmoeller, S.; Urbanowicz, M.; Flejou, J. F.; Kirsch, R.; Ciompi, F.; van der Laak, J. A. W. M.; Nagtegaal, I. D. (2020). Assessment of individual tumor buds using keratin immunohistochemistry: moderate interobserver agreement suggests a role for machine learning. Modern pathology, 33(5), pp. 825-833. Springer Nature 10.1038/s41379-019-0434-2
Zlobec, Inti; Dawson, Heather E.; Blank, Annika; Bokhorst, John-Melle; Berger, Martin D.; Nagtegaal, Iris D; Lugli, Alessandro (2020). Are tumour grade and tumour budding equivalent in colorectal cancer? A retrospective analysis of 771 patients. European journal of cancer, 130, pp. 139-145. Elsevier 10.1016/j.ejca.2020.02.007
Dawson, Heather; Christe, Lucine; Eichmann, Micha; Reinhard, Stefan; Zlobec, Inti; Blank, Annika; Lugli, Alessandro (2020). Tumour Budding/T-cell infiltrates in Colorectal Cancer: Proposal of a Novel Combined Score. Histopathology, 76(4), pp. 572-580. Wiley 10.1111/his.14006
Lugli, Alessandro; Zlobec, Inti (2020). The battle for prognosis at the invasive front of colorectal cancer. EBioMedicine, 58, p. 102918. Elsevier 10.1016/j.ebiom.2020.102918
Dawson, Heather; Galuppini, Francesca; Träger, Peter; Berger, Martin D.; Studer, Peter; Brügger, Lukas; Zlobec, Inti; Inderbitzin, Daniel; Lugli, Alessandro (2019). Validation of the international tumor budding consensus conference (ITBCC 2016) recommendations on tumor budding in stage I-IV colorectal cancer. Human pathology, 85, pp. 145-151. Elsevier 10.1016/j.humpath.2018.10.023
Wyss, Jacqueline; Dislich, Bastian; Kölzer, Viktor; Galván, José A.; Dawson, Heather; Hädrich, Marion; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti; Berger, Martin D. (2019). Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients. Clinical colorectal cancer, 18(1), e20-e38. Elsevier 10.1016/j.clcc.2018.09.007
Kienle, Dirk L.; Dietrich, Daniel; Ribi, Karin; Wicki, Andreas; Quagliata, Luca; Winterhalder, Ralph C.; Koeberle, Dieter; Horber, Daniel; Bastian, Sara; Kueng, Marc; Saletti, Piercarlo; Helbling, Daniel; Baertschi, Daniela; Lugli, Alessandro; Bernhard, Jürg; Andrieu, Christiane; von Moos, Roger (2019). Cetuximab monotherapy and cetuximab plus capecitabine as first-line treatment in older patients with RAS- and BRAF wild-type metastatic colorectal cancer. Results of the multicenter phase II trial SAKK 41/10. Journal of geriatric oncology, 10(2), pp. 304-310. Elsevier 10.1016/j.jgo.2018.11.011
Langer, Rupert; Tröhler, Alexandra; Schnüriger, Beat; Perren, Aurel; Blank, Annika; Banz Wälti, Yara; Trippel, Mafalda; Candinas, Daniel; Lugli, Alessandro (2019). Implementation of modern tools in autopsy practice-the way towards contemporary postmortal diagnostics. Virchows Archiv, 474(2), pp. 149-158. Springer 10.1007/s00428-018-2482-2
Georges, Laurent M. C.; De Wever, Olivier; Galván, José A.; Dawson, Heather; Lugli, Alessandro; Demetter, Pieter; Zlobec, Inti (2019). Cell Line Derived Xenograft Mouse Models Are a Suitable in vivo Model for Studying Tumor Budding in Colorectal Cancer. Frontiers in medicine, 6(139), p. 139. Frontiers 10.3389/fmed.2019.00139
Meyer, Sara N.; Galván, José A.; Zahnd, Stefan; Sokol, Lena; Dawson, Heather; Lugli, Alessandro; Zlobec, Inti (2019). Co-expression of cytokeratin and vimentin in colorectal cancer highlights a subset of tumor buds and an atypical cancer-associated stroma. Human pathology, 87, pp. 18-27. Elsevier 10.1016/j.humpath.2019.02.002
Blank, Annika; Schenker, Carla; Dawson, Heather; Beldi, Guido; Zlobec, Inti; Lugli, Alessandro (2019). Evaluation of Tumor Budding in Primary Colorectal Cancer and Corresponding Liver Metastases Based on H&E and Pancytokeratin Staining. Frontiers in medicine, 6, p. 247. Frontiers 10.3389/fmed.2019.00247
Trinh, Anne; Lädrach, Claudia; Dawson, Heather E.; Ten Hoorn, Sanne; Kuppen, Peter J K; Reimers, Marlies S; Koopman, Miriam; Punt, Cornelis J A; Lugli, Alessandro; Vermeulen, Louis; Zlobec, Inti (2018). Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data. British journal of cancer, 119(10), pp. 1244-1251. Nature Publishing Group 10.1038/s41416-018-0230-7
Zinnall, Ulrike; Weyerer, Veronika; Compérat, Eva; Camparo, Philippe; Gaisa, Nadine T; Knuechel-Clarke, Ruth; Perren, Aurel; Lugli, Alessandro; Toma, Marieta; Baretton, Gustavo; Kristiansen, Glen; Wirtz, Ralf M; Cheng, Liang; Wullich, Bernd; Stoehr, Robert; Hartmann, Arndt; Bertz, Simone (2018). Micropapillary urothelial carcinoma: evaluation of HER2 status and immunohistochemical characterization of the molecular subtype. Human pathology, 80, pp. 55-64. Elsevier 10.1016/j.humpath.2018.05.022
Graule, Janina; Uth-Gottardi, Kristin; Fischer, Elia Luca; Centeno Ramos, Irene; Galván Hernández, José Alberto; Eichmann, Micha David; Rau, Tilman; Langer, Rupert; Dawson, Heather; Nitsche, Ulrich; Traeger, Peter; Berger, Martin Dave; Schnüriger, Beat; Hädrich, Marion; Studer, Peter; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2018). CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway. Clinical epigenetics, 10(1), p. 120. Springer 10.1186/s13148-018-0548-2
Karamitopoulou, Evanthia; Wartenberg, Martin; Zlobec, Inti; Cibin, Silvia; Worni, Mathias; Gloor, Beat; Lugli, Alessandro (2018). Tumour budding in pancreatic cancer revisited: validation of the ITBCC scoring system. Histopathology, 73(1), pp. 137-146. Wiley 10.1111/his.13508
Pagès, Franck; Mlecnik, Bernhard; Marliot, Florence; Bindea, Gabriela; Ou, Fang-Shu; Bifulco, Carlo; Lugli, Alessandro; Zlobec, Inti; Rau, Tilman T.; Berger, Martin D.; Nagtegaal, Iris D; Vink-Börger, Elisa; Hartmann, Arndt; Geppert, Carol; Kolwelter, Julie; Merkel, Susanne; Grützmann, Robert; Van den Eynde, Marc; Jouret-Mourin, Anne; Kartheuser, Alex; ... (2018). International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet, 391(10135), pp. 2128-2139. Elsevier 10.1016/S0140-6736(18)30789-X
Zlobec, Inti; Lugli, Alessandro (2018). Tumour budding in colorectal cancer: molecular rationale for clinical translation. Nature reviews - cancer, 18(4), pp. 203-204. Nature Publishing Group 10.1038/nrc.2018.1
Vavricka, Stephan R; Galván Hernández, José Alberto; Dawson, Heather; Soltermann, Alex; Biedermann, Luc; Scharl, Michael; Schoepfer, Alain M; Rogler, Gerhard; Prinz Vavricka, Mareike B; Terracciano, Luigi; Navarini, Alexander; Zlobec, Inti; Lugli, Alessandro; Greuter, Thomas (2018). Expression Patterns of TNFα, MAdCAM1 and STAT3 in Intestinal and Skin Manifestations of Inflammatory Bowel Disease. Journal of Crohn's & colitis, 12(3), pp. 347-354. Oxford University Press 10.1093/ecco-jcc/jjx158
Blank, Annika; Roberts, Daniel Edward; Dawson, Heather; Zlobec, Inti; Lugli, Alessandro (2018). Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree? Frontiers in medicine, 5, p. 234. Frontiers 10.3389/fmed.2018.00234
Blank, Annika; Dawson, Heather; Hammer, Caroline; Perren, Aurel; Lugli, Alessandro (2017). [Lean management in the pathology laboratory]. Der Pathologe, 38(6), pp. 540-544. Springer 10.1007/s00292-017-0388-4
Galon, Jerome; Lugli, Alessandro; Bifulco, Carlo; Pages, Franck; Masucci, Giuseppe; Marincola, Francesco M; Ascierto, Paolo A (2017). World-Wide Immunoscore Task Force: meeting report from the "Melanoma Bridge", Napoli, November 30th-December 3rd, 2016. Journal of translational medicine, 15(1), p. 212. BioMed Central 10.1186/s12967-017-1310-9
Mele, Valentina; Sokol, Lena; Kölzer, Viktor; Pfaff, Dennis; Muraro, Manuele Giuseppe; Keller, Irene; Zahnd, Stefan Patrick; Centeno Ramos, Irene; Terracciano, Luigi Maria; Dawson, Heather; Zlobec, Inti; Iezzi, Giandomenica; Lugli, Alessandro (2017). The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer. OncoTarget, 8(41), pp. 70617-70629. Impact Journals LLC 10.18632/oncotarget.19904
Lugli, Alessandro; Kirsch, Richard; Ajioka, Yoichi; Bosman, Fred; Cathomas, Gieri; Dawson, Heather; El Zimaity, Hala; Fléjou, Jean-François; Hansen, Tine Plato; Hartmann, Arndt; Kakar, Sanjay; Langner, Cord; Nagtegaal, Iris; Puppa, Giacomo; Riddell, Robert; Ristimäki, Ari; Sheahan, Kieran; Smyrk, Thomas; Sugihara, Kenichi; Terris, Benoît; ... (2017). Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Modern pathology, 30(9), pp. 1299-1311. Nature Publishing Group 10.1038/modpathol.2017.46
Koelzer, Viktor H; Assarzadegan, Naziheh; Dawson, Heather; Mitrovic, Bojana; Grin, Andrea; Messenger, David E; Kirsch, Richard; Riddell, Robert H; Lugli, Alessandro; Zlobec, Inti (2017). Cytokeratin-based assessment of tumour budding in colorectal cancer: analysis in stage II patients and prospective diagnostic experience. The journal of pathology: clinical research, 3(3), pp. 171-178. Wiley 10.1002/cjp2.73
Rieger, Gregor; Kölzer, Viktor; Dawson, Heather; Berger, Martin Dave; Hädrich, Marion; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2017). Comprehensive assessment of tumour budding on cytokeratin stains in colorectal cancer. Histopathology, 70(7), pp. 1044-1051. Blackwell Scientific Publications 10.1111/his.13164
Koelzer, V H; Glatz, K; Bubendorf, L; Weber, A; Gaspert, A; Cathomas, G; Lugli, Alessandro; Zippelius, A; Kempf, W; Mertz, K D (2017). [The pathology of adverse events with immune checkpoint inhibitors]. Der Pathologe, 38(3), pp. 197-208. Springer 10.1007/s00292-017-0281-1
Ivanovska, Jelena; Zlobec, Inti; Forster, Stefan; Karamitopoulou, Evanthia; Dawson, Heather; Koelzer, Viktor Hendrik; Agaimy, Abbas; Garreis, Fabian; Söder, Stephan; Laqua, William; Lugli, Alessandro; Hartmann, Arndt; Rau, Tilman; Schneider-Stock, Regine (2017). Correction: DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells. OncoTarget, 8(11), pp. 18615-18616. Impact Journals LLC 10.18632/oncotarget.16154
Nolte, Sarah; Zlobec, Inti; Lugli, Alessandro; Hohenberger, Werner; Croner, Roland; Merkel, Susanne; Hartmann, Arndt; Geppert, Carol I; Rau, Tilman (2017). Construction and analysis of tissue microarrays in the era of digital pathology: a pilot study targeting CDX1 and CDX2 in a colon cancer cohort of 612 patients. The journal of pathology: clinical research, 3(1), pp. 58-70. Wiley 10.1002/cjp2.62
Centeno, Irene; Paasinen Sohns, Aino; Flury, Miriam; Galván, José A.; Zahnd, Stefan; Kölzer, Viktor H.; Sokol, Lena; Dawson, Heather E.; Lugli, Alessandro; Cathomas, Gieri; Zlobec, Inti (2017). DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive. Virchows Archiv, 470(3), pp. 341-346. Springer 10.1007/s00428-017-2071-9
Kölzer, Viktor; Sokol, Lena; Zahnd, Stefan Patrick; Christe, Lucine; Dawson, Heather; Berger, Martin Dave; Inderbitzin, Daniel; Zlobec, Inti; Lugli, Alessandro (2017). Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer. Oncoimmunology, 6(4), e1288330. Landes Bioscience 10.1080/2162402X.2017.1288330
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Helbling, Melina; Lukesch, Anne Carolin; Haimovici, Aladin; Karamitopoulou, Evanthia; Berger, Martin Dave; Hädrich, Marion; Mallaev, Makhmud; Schnüriger, Beat; Kölzer, Viktor; Dawson, Heather; Borner, Markus; Langer, Rupert; Rosenberg, Robert; Nitsche, Ulrich; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2014). Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients. OncoTarget, 5(13), pp. 4671-4682. Impact Journals LLC
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Droeser, Raoul A.; Hirt, Christian; Viehl, Carsten T.; Frey, Daniel M.; Nebiker, Christian; Huber, Xaver; Zlobec, Inti; Eppenberger-Castori, Serenella; Tzankov, Alexander; Rosso, Raffaele; Zuber, Markus; Muraro, Manuele Giuseppe; Amicarella, Francesca; Cremonesi, Eleonora; Heberer, Michael; Iezzi, Giandomenica; Lugli, Alessandro; Terracciano, Luigi; Sconocchia, Giuseppe; Oertli, Daniel; ... (2013). Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. European journal of cancer, 49(9), pp. 2233-2242. Elsevier 10.1016/j.ejca.2013.02.015
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Dawson, Heather; Kölzer, Viktor H.; Lukesch, Anne C.; Mallaev, Makhmudbek; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2013). Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer. Frontiers in oncology, 3, p. 265. Frontiers Research Foundation 10.3389/fonc.2013.00265
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Karamitopoulou, Evanthia; Zlobec, Inti; Gloor, Beat; Kondi-Pafiti, Agathi; Lugli, Alessandro; Perren, Aurel (2013). Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC). Journal of translational medicine, 11, p. 311. BioMed Central 10.1186/1479-5876-11-311
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Karamitopoulou, Evanthia; Zlobec, Inti; Perren, Aurel; Gloor, Beat; Lugli, Alessandro (2013). Increased tumor-budding/CD8+lymphocytes ratio is associated with metastasis and venous invasion in Pancreatic Ductal Adenocarcinoma (PDAC). Virchows Archiv, 463(2), p. 106. Springer
Zlobec, Inti; Kölzer, Viktor; Dawson, Heather; Langer, Rupert; Karamitopoulou, Evanthia; Lugli, Alessandro (2013). Investigation of IL23 (p19, p40) and IL23R highlights nuclear IL23p19 expression as a marker of indolent tumor features and favorable outcome in colorectal cancer patients. Virchows Archiv, 463(2), pp. 139-140. Springer 10.1007/s00428-013-1444-y
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Zlobec, I.; Helbling, M.; Dawson, Heather; Kölzer, V. H.; Karamitopoulou, E.; Lugli, A. (2013). ZEB2 CpG promoter methylation in colorectal cancer is associated with lymph node metastases and invasion in KRAS wild-type patients. Pathologe, 34(6), p. 592. Springer-Medizin-Verlag
Diamantis-Karamitopoulou, E.; Lugli, A.; Gloor, B.; Perren, A.; Zlobec, I. (2013). Decreased CD8+ lymphocytes/tumor budding ratio is associated with metastasis and venous invasion in pancreatic ductal adenocarcinoma (PDAC). Pathologe, 34(6), p. 601. Springer-Medizin-Verlag
Dawson, Heather; Kölzer, Viktor; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). TrkB expression in colorectal cancers highlights anoiks-resistance as a possible survival mechanism of tumor budding (EMT-like) cells. Pathologe, 34(6), pp. 602-603. Springer-Medizin-Verlag
Zlobec, I.; Helbling, M.; Karamitopoulou, E.; Dawson, Heather; Kölzer, V. H.; Lugli, A. (2013). CpG promoter hypermethylation of CTNNB1 (B-catenin) and TWIST2 promote a high-grade tumor budding phenotype in colorectal cancer. Pathologe, 34(6), p. 603. Springer-Medizin-Verlag
Kölzer, Viktor; Zlobec, Inti; Dawson, Heather; Lugli, Alessandro (2013). CD8/CD45RO T-cell infiiltration in pre-operative biopsies of colorectal cancer predicts histopathologic features of the matched reseaction specimen and survival outcome. Pathologe, 34(6), p. 603. Springer-Medizin-Verlag
Kölzer, Viktor; Canonica, Katharina; Dawson, Heather; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). Stromal macrophages closely interact with infiltrating tumor cells in the tumor microenvironemnt of colorectal cancer. Pathologe, 34(6), p. 604. Springer-Medizin-Verlag
Dawson, Heather; Hädrich, Marion; Kölzer, Viktor; Borner, Markus; Mallaev, M.; Schnüriger, Beat; Inderbitzin, Daniel; Zlobec, Inti; Lugli, Alessandro (2013). Intratumoral budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastasis in colon and rectal cancer patients. Pathologe, 34(6), p. 602. Springer-Medizin-Verlag
Dawson, Heather; Helbling, Melina; Karamitopoulou, Evanthia; Kölzer, Viktor; Lugli, Alessandro; Zlobec, Inti (2013). Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. Pathologe, 34(6), pp. 591-592. Springer-Medizin-Verlag
Karamitopoulou, Evanthia; Zlobec, Inti; Gloor, Beat; Kondi-Pafiti, A.; Lugli, Alessandro; Perren, Aurel (2013). Loss of Raf-1 Kinase Inhibitor Protein (RKIP) promotes Epithelial Mesenchymal Transition (EMT) and correlates with aggressive phenotype in Pancreatic Ductal Adenocarcinoma (PDAC). Virchows Archiv, 463(2), p. 139. Springer
Kölzer, Viktor; Dawson, Heather; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). Island methylator phenotype and mismatch repair- deficiency. Modern pathology, 24(161A). Nature Publishing Group
Horcic, Milo; Koelzer, Viktor H; Karamitopoulou, Eva; Terracciano, Luigi; Puppa, Giacomo; Zlobec, Inti; Lugli, Alessandro (2012). Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer. Human pathology, 44(5), pp. 697-705. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2012.07.026
Lugli, A; Karamitopoulou, Eva; Zlobec, I (2012). Tumour budding: a promising parameter in colorectal cancer. British journal of cancer, 106(11), pp. 1713-7. Basingstoke: Nature Publishing Group 10.1038/bjc.2012.127
Galon, Jérôme; Pagès, Franck; Marincola, Francesco M.; Angell, Helen K.; Thurin, Magdalena; Lugli, Alessandro; Zlobec, Inti; Berger, Anne; Bifulco, Carlo; Botti, Gerardo; Tatangelo, Fabiana; Britten, Cedrik M.; Kreiter, Sebastian; Chouchane, Lotfi; Delrio, Paolo; Arndt, Hartmann; Asslaber, Martin; Maio, Michele; Masucci, Giuseppe V.; Mihm, Martin; ... (2012). Cancer classification using the Immunoscore: a worldwide task force. Journal of translational medicine, 10, p. 205. London: BioMed Central 10.1186/1479-5876-10-205
Bihl, Michel P.; Foerster, Anja; Lugli, Alessandro; Zlobec, Inti (2012). Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing. Journal of translational medicine, 10, p. 173. London: BioMed Central 10.1186/1479-5876-10-173
Zlobec, Inti; Borner, Markus; Lugli, Alessandro; Inderbitzin, Daniel (2012). Role of intra- and peritumoral budding in the interdisciplinary management of rectal cancer patients. International journal of surgical oncology, 2012, p. 795945. New York, N.Y.: Hindawi 10.1155/2012/795945
Zlobec, Inti; Bihl, Michel P; Foerster, Anja; Rufle, Alex; Lugli, Alessandro (2012). The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer. Histopathology, 61(5), pp. 777-87. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2012.04273.x
Puppa, Giacomo; Senore, Carlo; Sheahan, Kieran; Vieth, Michael; Lugli, Alessandro; Zlobec, Inti; Pecori, Sara; Wang, Lai Mun; Langner, Cord; Mitomi, Hiroyuki; Nakamura, Takatoshi; Watanabe, Masahiko; Ueno, Hideki; Chasle, Jacques; Conley, Stephen A; Herlin, Paulette; Lauwers, Gregory Y; Risio, Mauro (2012). Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy. Histopathology, 61(4), pp. 562-575. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2012.04270.x
Zlobec, Inti; Bihl, Michel P; Foerster, Anja; Rufle, Alex; Terracciano, Luigi; Lugli, Alessandro (2012). Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer. Frontiers in oncology, 2, p. 7. Lausanne: Frontiers Research Foundation 10.3389/fonc.2012.00007
Giger, Olivier T; Comtesse, Sarah C M; Lugli, Alessandro; Zlobec, Inti; Kurrer, Michael O (2012). Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer. Modern pathology, 25(7), pp. 1048-53. London: Nature Publishing Group 10.1038/modpathol.2012.56
Pfammatter, Chantal; Lindenmüller, Irène Hitz; Lugli, Alessandro; Filippi, Andreas; Kühl, Sebastian (2012). Metastases and primary tumors around dental implants: A literature review and case report of peri-implant pulmonary metastasis. Quintessence international, 43(7), pp. 563-70. Berlin: Quintessenz Verlags-GmbH
Lugli, Alessandro; Hädrich, Marion; Inderbitzin, D; Borner, Markus; Zlobec, Inti (2012). Intratumoral budding is preoperative biopsies predicts local and distant metastasis in colorectal cancer patients. Virchows Archiv, 461(1 (Sup), S11. Springer
Zlobec, Inti; Karamitopoulou, Evanthia; Terracciano, Luigi; Inderbitzin, Daniel; Lugli, Alessandro (2012). Prognostic impact of lymph node ratio outperforms positive lymph nodes and lymph nodes harvested: a time-dependent analysis in mismatch repair-proficient and –deficient colrectal cancers. Virchows Archiv, 461(1), S191. Springer
Lugli, Alessandro; Vlajnic, Tatjana; Giger, Olivier; Karamitopoulou, Eva; Patsouris, Efstratios S; Peros, George; Terracciano, Luigi M; Zlobec, Inti (2011). Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients. Human pathology, 42(12), pp. 1833-40. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2011.02.010
Zlobec, Inti; Bihl, Michel; Foerster, Anja; Rufle, Alex; Lugli, Alessandro (2011). Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. Journal of pathology, 225(3), pp. 336-43. Chichester: Wiley 10.1002/path.2879
Lugli, A; Zlobec, I (2011). Gene signatures in colorectal cancer. In: Russo A, Iacobelli S (ed.) Diagnostic, prognostic and therapeutic value of gene signatures (pp. 115-136). Berlin-Heidelberg: Springer
