Paracetamol for perioperative analgesia. Old substance - new insights

Zahn, P K; Sabatowski, R; Schug, S A; Stamer, Ulrike; Pogatzki-Zahn, E M (2010). Paracetamol for perioperative analgesia. Old substance - new insights. Der Anaesthesist, 59(10), pp. 940-952. Springer 10.1007/s00101-010-1773-z

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Since paracetamol was first synthesized in 1878 it has become one of the most popular and widely used drugs for the first-line treatment of fever and pain. The reasons for this popularity are a wide variety of formulations, an assumed positive safety record and the wide availability as an over-the-counter drug. However, recently several studies questioned the positive risk-benefit ratio of paracetamol for postoperative pain by observing several possible adverse effects and limitations. The aim of the present review is to give an update of the recent literature on the efficacy of paracetamol for postoperative pain and on the value of the clinical relevance of different adverse effects of paracetamol. Finally, based on the current findings the authors try to assess the role of paracetamol for the treatment of postoperative pain.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Stamer, Ulrike


600 Technology > 610 Medicine & health








Jeannie Wurz

Date Deposited:

17 Jul 2015 16:23

Last Modified:

23 Jan 2018 12:16

Publisher DOI:


PubMed ID:



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