Hybrid Breakdown in Cichlid Fish

Stelkens, Rike Bahati; Schmid, Corinne; Seehausen, Ole (2015). Hybrid Breakdown in Cichlid Fish. PLoS ONE, 10(5), e0127207. Public Library of Science 10.1371/journal.pone.0127207

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Studies from a wide diversity of taxa have shown a negative relationship between genetic compatibility and the divergence time of hybridizing genomes. Theory predicts the main breakdown of fitness to happen after the F1 hybrid generation, when heterosis subsides and recessive allelic (Dobzhansky-Muller) incompatibilities are increasingly unmasked. We measured the fitness of F2 hybrids of African haplochromine cichlid fish bred from species pairs spanning several thousand to several million years divergence time. F2 hybrids consistently showed the lowest viability compared to F1 hybrids and non-hybrid crosses (crosses within the grandparental species), in agreement with hybrid breakdown. Especially the short- and long-term survival (2 weeks to 6 months) of F2 hybrids was significantly reduced. Overall, F2 hybrids showed a fitness reduction of 21% compared to F1 hybrids, and a reduction of 43% compared to the grandparental, non-hybrid crosses. We further observed a decrease of F2 hybrid viability with the genetic distance between grandparental lineages, suggesting an important role for negative epistatic interactions in cichlid fish postzygotic isolation. The estimated time window for successful production of F2 hybrids resulting from our data is consistent with the estimated divergence time between the multiple ancestral lineages that presumably hybridized in three major adaptive radiations of African cichlids.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Aquatic Ecology

UniBE Contributor:

Stelkens, Rike Bahati and Seehausen, Ole

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Marcel Häsler

Date Deposited:

22 Jul 2015 11:04

Last Modified:

22 Jul 2015 11:04

Publisher DOI:

10.1371/journal.pone.0127207

PubMed ID:

25996870

BORIS DOI:

10.7892/boris.70403

URI:

https://boris.unibe.ch/id/eprint/70403

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