A comparative radiation hybrid map of sheep chromosome 10

Drögemüller, Michaela; Tetens, Jens; Dalrymple, B; Goldammer, T; Wu, C H; Cockett, N E; Leeb, Tosso; Drögemüller, Cord (2008). A comparative radiation hybrid map of sheep chromosome 10. Cytogenetic and genome research, 121(1), pp. 35-40. Karger 10.1159/000124379

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Comparative radiation hybrid (RH) maps of individual ovine chromosomes are essential to identify genes governing traits of economic importance in sheep, a livestock species for which whole genome sequence data are not yet available. The USUoRH5000 radiation hybrid panel was used to generate a RH map of sheep chromosome 10 (OAR10) with 59 markers that span 1,422 cR over an estimated 92 Mb of the chromosome, thus providing markers every 2 Mb (equivalent to every 24 cR). The markers were derived from 46 BAC end sequences (BESs), a single EST, and 12 microsatellites. Comparative analysis showed that OAR10 shares remarkable conservation of gene order along the entire length of cattle chromosome 12 and that OAR10 contains four major homologous synteny blocks, each related to segments of the homologous human chromosome 13. Extending the comparison to the horse, dog, mouse, and chicken genome showed that these blocks share conserved synteny across species.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Drögemüller, Michaela; Tetens, Jens; Leeb, Tosso and Drögemüller, Cord

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

1424-8581

Publisher:

Karger

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

17 Aug 2015 14:13

Last Modified:

18 Aug 2015 02:47

Publisher DOI:

10.1159/000124379

PubMed ID:

18544924

BORIS DOI:

10.7892/boris.70782

URI:

https://boris.unibe.ch/id/eprint/70782

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