Keiser, Olivia; Blaser, Nello; Davies, Mary-Ann; Wessa, Patrick; Eley, Brian; Moultrie, Harry; Rabie, Helena; Technau, Karl; Ndirangu, James; Garone, Daniela; Giddy, Janet; Grimwood, Ashraf; Gsponer, Thomas; Egger, Matthias (2015). Growth in Virologically Suppressed HIV Positive Children on Antiretroviral Therapy: Individual and Population-Level References. The Pediatric infectious disease journal, 34(10), e254-9. Lippincott Williams & Wilkins 10.1097/INF.0000000000000801
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BACKGROUND
Combination antiretroviral therapy (ART) suppresses viral replication in HIV-infected children. The growth of virologically suppressed children on ART has not been well documented. We aimed to develop dynamic reference curves for weight-for-age z scores (WAZ) and height-for-age z scores (HAZ).
RESULTS
A total of 4,876 children were followed for 7,407 person-years. Analyses were stratified by baseline z-scores and age, which were the most important predictors of growth response. The youngest children showed the most pronounced increase in weight and height initially but catch-up growth stagnated after 1-2 years. Three years after starting ART, WAZ ranged from -2.2 (95% Prediction interval -5.6 to 0.8) in children with baseline age "5 years and z-score "-3 to 0.0 (-2.7 to 2.4) in children with baseline age "2 years and WAZ "-1. For HAZ the corresponding range was -2.3 (-4.9 to 0.3) in children with baseline age"5 years and z-score "-3 to 0.3 (-3.1 to 3.4) in children with baseline age 2-5 years and HAZ "-1.
CONCLUSIONS
We have developed an online tool to calculate reference trajectories in fully suppressed children. The web application could help to define 'optimal' growth response and identify children with treatment failure.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Keiser, Olivia, Blaser, Nello, Gsponer, Thomas, Egger, Matthias |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1532-0987 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Doris Kopp Heim |
Date Deposited: |
11 Aug 2015 15:18 |
Last Modified: |
05 Dec 2022 14:48 |
Publisher DOI: |
10.1097/INF.0000000000000801 |
PubMed ID: |
26192393 |
BORIS DOI: |
10.7892/boris.70946 |
URI: |
https://boris.unibe.ch/id/eprint/70946 |
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