Growth in Virologically Suppressed HIV Positive Children on Antiretroviral Therapy: Individual and Population-Level References

Keiser, Olivia; Blaser, Nello; Davies, Mary-Ann; Wessa, Patrick; Eley, Brian; Moultrie, Harry; Rabie, Helena; Technau, Karl; Ndirangu, James; Garone, Daniela; Giddy, Janet; Grimwood, Ashraf; Gsponer, Thomas; Egger, Matthias (2015). Growth in Virologically Suppressed HIV Positive Children on Antiretroviral Therapy: Individual and Population-Level References. The Pediatric infectious disease journal, 34(10), e254-9. Lippincott Williams & Wilkins 10.1097/INF.0000000000000801

[img]
Preview
Text
Keiser PediatrInfectDisJ 2015_accepted.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (1MB) | Preview
[img]
Preview
Text
Keiser PediatrInfectDisJ 2015.pdf - Published Version
Available under License Publisher holds Copyright.

Download (715kB) | Preview

BACKGROUND Combination antiretroviral therapy (ART) suppresses viral replication in HIV-infected children. The growth of virologically suppressed children on ART has not been well documented. We aimed to develop dynamic reference curves for weight-for-age z scores (WAZ) and height-for-age z scores (HAZ). RESULTS A total of 4,876 children were followed for 7,407 person-years. Analyses were stratified by baseline z-scores and age, which were the most important predictors of growth response. The youngest children showed the most pronounced increase in weight and height initially but catch-up growth stagnated after 1-2 years. Three years after starting ART, WAZ ranged from -2.2 (95% Prediction interval -5.6 to 0.8) in children with baseline age "5 years and z-score "-3 to 0.0 (-2.7 to 2.4) in children with baseline age "2 years and WAZ "-1. For HAZ the corresponding range was -2.3 (-4.9 to 0.3) in children with baseline age"5 years and z-score "-3 to 0.3 (-3.1 to 3.4) in children with baseline age 2-5 years and HAZ "-1. CONCLUSIONS We have developed an online tool to calculate reference trajectories in fully suppressed children. The web application could help to define 'optimal' growth response and identify children with treatment failure.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Keiser, Olivia; Blaser, Nello; Gsponer, Thomas and Egger, Matthias

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1532-0987

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

11 Aug 2015 15:18

Last Modified:

09 Sep 2017 22:34

Publisher DOI:

10.1097/INF.0000000000000801

PubMed ID:

26192393

BORIS DOI:

10.7892/boris.70946

URI:

https://boris.unibe.ch/id/eprint/70946

Actions (login required)

Edit item Edit item
Provide Feedback