Imaging of the spleen in malaria

Ferrer, Mireia; Martin-Jaular, Lorena; De Niz Hidalgo, Mariana Isabel; Khan, Shahid M; Janse, Chris J; Calvo, Maria; Heussler, Volker; del Portillo, Hernando A (2014). Imaging of the spleen in malaria. Parasitology international, 63(1), pp. 195-205. Elsevier 10.1016/j.parint.2013.08.014

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Splenomegaly, albeit variably, is a hallmark of malaria; yet, the role of the spleen in Plasmodium infections remains vastly unknown. The implementation of imaging to study the spleen is rapidly advancing our knowledge of this so-called "blackbox" of the abdominal cavity. Not only has ex vivo imaging revealed the complex functional compartmentalization of the organ and immune effector cells, but it has also allowed the observation of major structural remodeling during infections. In vivo imaging, on the other hand, has allowed quantitative measurements of the dynamic passage of the parasite at spatial and temporal resolution. Here, we review imaging techniques used for studying the malarious spleen, from optical microscopy to in vivo imaging, and discuss the bright perspectives of evolving technologies in our present understanding of the role of this organ in infections caused by Plasmodium.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

De Niz Hidalgo, Mariana Isabel and Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1383-5769

Publisher:

Elsevier

Language:

English

Submitter:

Volker Heussler

Date Deposited:

14 Aug 2015 11:58

Last Modified:

22 Apr 2020 15:17

Publisher DOI:

10.1016/j.parint.2013.08.014

PubMed ID:

23999413

BORIS DOI:

10.7892/boris.71014

URI:

https://boris.unibe.ch/id/eprint/71014

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