Widespread Signals of Convergent Adaptation to High Altitude in Asia and America

Foll, Matthieu; Gaggiotti, Oscar; Daub, Joséphine; Vatsiou, Alexandra; Excoffier, Laurent (2014). Widespread Signals of Convergent Adaptation to High Altitude in Asia and America. American journal of human genetics, 95(4), pp. 394-407. Cell Press 10.1016/j.ajhg.2014.09.002

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Living at high altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean, and Ethiopian populations, relatively little evidence of convergent evolution to altitude in different continents has accumulated. This lack of evidence can be due to truly different evolutionary responses, but it can also be due to the low power of former studies that have mainly focused on populations from a single geographical region or performed separate analyses on multiple pairs of populations to avoid problems linked to shared histories between some populations. We introduce here a hierarchical Bayesian method to detect local adaptation that can deal with complex demographic histories. Our method can identify selection occurring at different scales, as well as convergent adaptation in different regions. We apply our approach to the analysis of a large SNP data set from low- and high-altitude human populations from America and Asia. The simultaneous analysis of these two geographic areas allows us to identify several candidate genome regions for altitudinal selection, and we show that convergent evolution among continents has been quite common. In addition to identifying several genes and biological processes involved in high-altitude adaptation, we identify two specific biological pathways that could have evolved in both continents to counter toxic effects induced by hypoxia.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Population Genetics
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)

UniBE Contributor:

Foll, Matthieu; Daub, Joséphine and Excoffier, Laurent

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0002-9297

Publisher:

Cell Press

Language:

English

Submitter:

Isabelle Duperret

Date Deposited:

09 Sep 2015 16:37

Last Modified:

09 Sep 2015 16:37

Publisher DOI:

10.1016/j.ajhg.2014.09.002

PubMed ID:

25262650

BORIS DOI:

10.7892/boris.71386

URI:

https://boris.unibe.ch/id/eprint/71386

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