Impact of range expansions on current human genomic diversity

Martins Conde e Sousa, Vitor; Peischl, Stephan; Excoffier, Laurent (2014). Impact of range expansions on current human genomic diversity. Current opinion in genetics & development, 29, pp. 22-30. Elsevier 10.1016/j.gde.2014.07.007

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The patterns of population genetic diversity depend to a large extent on past demographic history. Most human populations are known to have gone recently through a series of range expansions within and out of Africa, but these spatial expansions are rarely taken into account when interpreting observed genomic diversity, possibly because they are difficult to model. Here we review available evidence in favour of range expansions out of Africa, and we discuss several of their consequences on neutral and selected diversity, including some recent observations on an excess of rare neutral and selected variants in large samples. We further show that in spatially subdivided populations, the sampling strategy can severely impact the resulting genetic diversity and be confounded by past demography. We conclude that ignoring the spatial structure of human population can lead to some misinterpretations of extant genetic diversity.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Population Genetics
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)

UniBE Contributor:

Martins Conde e Sousa, Vitor; Peischl, Stephan and Excoffier, Laurent

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0959-437X

Publisher:

Elsevier

Language:

English

Submitter:

Isabelle Duperret

Date Deposited:

04 Sep 2015 13:58

Last Modified:

04 Sep 2015 13:58

Publisher DOI:

10.1016/j.gde.2014.07.007

BORIS DOI:

10.7892/boris.71409

URI:

https://boris.unibe.ch/id/eprint/71409

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