Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis

Keiser, Olivia; Spycher, Ben; Rauch, Andri; Calmy, Alexandra; Cavassini, Matthias; Glass, Tracy R; Nicca, Dunja; Ledergerber, Bruno; Egger, Matthias; Swiss HIV Cohort Study, (2012). Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis. AIDS and behavior, 16(2), pp. 245-55. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s10461-011-9971-5

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An in-depth understanding of the different groups that make up the HIV-infected population should inform prevention and care. Using latent class analysis (LCA) we identified seven groups with similar socio-demographic and behavioral characteristics at enrolment in the Swiss HIV Cohort Study: older gay men, younger gay men, older heterosexual men, injection drug users, single migrants, migrant women in partnerships and heterosexual men and women. Outcomes of combination antiretroviral therapy (ART) were analyzed in 1,633 patients starting ART. Compared to older gay men, the probability of a virologic response to ART was reduced in single migrants, in older heterosexual men and in IDUs. Loss to follow-up was higher in single migrants and IDUs, and mortality was increased in older heterosexual men and IDUs. Socio-behavioral groups identified by LCA allow insights above what can be gleaned from traditional transmission groups, and may identify patients who could benefit from targeted interventions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Keiser, Olivia; Spycher, Ben and Egger, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1090-7165

Publisher:

Springer US; http://www.springer-ny.com

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

25 Oct 2019 02:46

Publisher DOI:

10.1007/s10461-011-9971-5

PubMed ID:

21630013

Web of Science ID:

000300278300001

BORIS DOI:

10.7892/boris.7312

URI:

https://boris.unibe.ch/id/eprint/7312 (FactScience: 212510)

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