Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs

Furrer, Julien; Süss-Fink, Georg (2016). Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs. Coordination Chemistry Reviews, 309, pp. 36-50. Elsevier 10.1016/j.ccr.2015.10.007

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Water-soluble arene ruthenium complexes have been intensively studied as cytotoxic compounds for the last fifteen years, notably owing to the promising in vitro and in vivo evaluations of, respectively, RAPTA-C (η6-p-MeC6H4Pri)Ru(P-pta)Cl2 (pta = 1,3,5-triaza-7-phospha-tricyclo-[3.3.1.1]decane) from Dyson's laboratory, and the (η6-arene)Ru(en)Cl]+ (en = ethylenediamine, RAED) family of compounds from Sadler's laboratory. In this account we describe the discovery of thiolato-bridged dinuclear arene ruthenium complexes and highlight subsequent developments in the field, including their syntheses, structures, and the recent strategies for the design of thiolato-bridged dinuclear arene ruthenium bioconjugates.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Furrer, Julien

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0010-8545

Publisher:

Elsevier

Language:

English

Submitter:

Julien Henri Lucien Furrer

Date Deposited:

14 Dec 2015 08:46

Last Modified:

16 Dec 2015 02:51

Publisher DOI:

10.1016/j.ccr.2015.10.007

BORIS DOI:

10.7892/boris.73621

URI:

https://boris.unibe.ch/id/eprint/73621

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