Experimental validation of a nonlinear μ FE model based on cohesive-frictional plasticity for trabecular bone

Schwiedrzik, J.; Gross, T.; Bina, M.; Pretterklieber, M.; Zysset, Philippe; Pahr, D. (2016). Experimental validation of a nonlinear μ FE model based on cohesive-frictional plasticity for trabecular bone. International Journal for Numerical Methods in Biomedical Engineering, 32(4), e02739. Wiley 10.1002/cnm.2739

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Trabecular bone is a porous mineralized tissue playing a major load bearing role in the human body. Prediction of age-related and disease-related fractures and the behavior of bone implant systems needs a thorough understanding of its structure-mechanical property relationships, which can be obtained using microcomputed tomography-based finite element modeling. In this study, a nonlinear model for trabecular bone as a cohesive-frictional material was implemented in a large-scale computational framework and validated by comparison of μFE simulations with experimental tests in uniaxial tension and compression. A good correspondence of stiffness and yield points between simulations and experiments was found for a wide range of bone volume fraction and degree of anisotropy in both tension and compression using a non-calibrated, average set of material parameters. These results demonstrate the ability of the model to capture the effects leading to failure of bone for three anatomical sites and several donors, which may be used to determine the apparent behavior of trabecular bone and its evolution with age, disease, and treatment in the future.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Schwiedrzik, Johann Jakob and Zysset, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2040-7947

Publisher:

Wiley

Language:

English

Submitter:

Philippe Zysset

Date Deposited:

14 Dec 2015 12:00

Last Modified:

24 Jan 2019 10:15

Publisher DOI:

10.1002/cnm.2739

PubMed ID:

26224581

BORIS DOI:

10.7892/boris.74245

URI:

https://boris.unibe.ch/id/eprint/74245

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