The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Schotten, Ulrich; Hatem, Stephane; Ravens, Ursula; Jaïs, Pierre; Müller, Frank-Ulrich; Goette, Andres; Rohr, Stephan; Antoons, Gudrun; Pieske, Burkert; Scherr, Daniel; Oto, Ali; Casadei, Barbara; Verheule, Sander; Cartlidge, David; Steinmeyer, Klaus; Götsche, Thorsten; Dobrev, Dobromir; Kockskämper, Jens; Lendeckel, Uwe; Fabritz, Larissa; ... (2015). The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace, 17(10), pp. 1457-1466. Oxford University Press 10.1093/europace/euv252

Preview	Text euv252.pdf - Published Version Available under License Publisher holds Copyright. Download (827kB) | Preview
	Slideshow (Figures) Fgures EUTRAF.pptx - Supplemental Material Available under License Publisher holds Copyright. Download (4MB)
Preview	Text EUTRAF%20Review%20article%20150205%20final-1.pdf - Accepted Version Available under License Publisher holds Copyright. Download (181kB) | Preview

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this network.

Interest & Impact

Downloads

497 since deposited on 13 Jan 2016
25 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item