Prognostic and diagnostic value of EEG signal coupling measures in coma.

Zubler, Frederic; Koenig, Christa; Steimer, Andreas; Jakob, Stephan; Schindler, Kaspar Anton; Gast, Heidemarie (2015). Prognostic and diagnostic value of EEG signal coupling measures in coma. Clinical neurophysiology, 127(8), pp. 2942-2952. Elsevier 10.1016/j.clinph.2015.08.022

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OBJECTIVE Our aim was to assess the diagnostic and predictive value of several quantitative EEG (qEEG) analysis methods in comatose patients. METHODS In 79 patients, coupling between EEG signals on the left-right (inter-hemispheric) axis and on the anterior-posterior (intra-hemispheric) axis was measured with four synchronization measures: relative delta power asymmetry, cross-correlation, symbolic mutual information and transfer entropy directionality. Results were compared with etiology of coma and clinical outcome. Using cross-validation, the predictive value of measure combinations was assessed with a Bayes classifier with mixture of Gaussians. RESULTS Five of eight measures showed a statistically significant difference between patients grouped according to outcome; one measure revealed differences in patients grouped according to the etiology. Interestingly, a high level of synchrony between the left and right hemisphere was associated with mortality on intensive care unit, whereas higher synchrony between anterior and posterior brain regions was associated with survival. The combination with the best predictive value reached an area-under the curve of 0.875 (for patients with post anoxic encephalopathy: 0.946). CONCLUSIONS EEG synchronization measures can contribute to clinical assessment, and provide new approaches for understanding the pathophysiology of coma. SIGNIFICANCE Prognostication in coma remains a challenging task. qEEG could improve current multi-modal approaches.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Steimer, Andreas; Jakob, Stephan; Schindler, Kaspar Anton and Gast, Heidemarie


600 Technology > 610 Medicine & health








Romina Theiler

Date Deposited:

28 Jan 2016 16:43

Last Modified:

19 Jul 2016 01:30

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Bayes classifier; Coma Prognostication; Quantitative EEG Synchronization




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