Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude.

Garde, A; Giraldo, B F; Jané, R; Latshang, T D; Turk, A J; Hess, T; Bosch, M M; Barthelmes, D; Merz, Tobias Michael; Pichler Hefti, Jacqueline Renée; Schoch, O D; Bloch, K E (2015). Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude. Medical & biological engineering & computing, 53(8), pp. 699-712. Springer 10.1007/s11517-015-1275-x

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This work investigates the performance of cardiorespiratory analysis detecting periodic breathing (PB) in chest wall recordings in mountaineers climbing to extreme altitude. The breathing patterns of 34 mountaineers were monitored unobtrusively by inductance plethysmography, ECG and pulse oximetry using a portable recorder during climbs at altitudes between 4497 and 7546 m on Mt. Muztagh Ata. The minute ventilation (VE) and heart rate (HR) signals were studied, to identify visually scored PB, applying time-varying spectral, coherence and entropy analysis. In 411 climbing periods, 30-120 min in duration, high values of mean power (MP(VE)) and slope (MSlope(VE)) of the modulation frequency band of VE, accurately identified PB, with an area under the ROC curve of 88 and 89%, respectively. Prolonged stay at altitude was associated with an increase in PB. During PB episodes, higher peak power of ventilatory (MP(VE)) and cardiac (MP(LF)(HR) ) oscillations and cardiorespiratory coherence (MP(LF)(Coher)), but reduced ventilation entropy (SampEn(VE)), was observed. Therefore, the characterization of cardiorespiratory dynamics by the analysis of VE and HR signals accurately identifies PB and effects of altitude acclimatization, providing promising tools for investigating physiologic effects of environmental exposures and diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Merz, Tobias Michael and Pichler Hefti, Jacqueline Renée

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0140-0118

Publisher:

Springer

Language:

English

Submitter:

Alessandra Angelini

Date Deposited:

04 Feb 2016 10:21

Last Modified:

29 Feb 2016 15:12

Publisher DOI:

10.1007/s11517-015-1275-x

PubMed ID:

25820153

BORIS DOI:

10.7892/boris.74870

URI:

https://boris.unibe.ch/id/eprint/74870

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