Jörger Messerli, Marianne; Marx, Caterina; Oppliger, Byron; Müller, Martin; Surbek, Daniel; Schoeberlein, Andreina (2016). Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid. Best Practice & Research Clinical Obstetrics & Gynaecology, 31, pp. 30-44. Elsevier 10.1016/j.bpobgyn.2015.07.006
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The discovery of mesenchymal stem cells (MSCs) in perinatal sources, such as the amniotic fluid (AF) and the umbilical connective tissue, the so-called Wharton's jelly (WJ), has transformed them into promising stem cell grafts for the application in regenerative medicine. The advantages of AF-MSCs and WJ-MSCs over adult MSCs, such as bone marrow-derived mesenchymal stem cells (BMMSCs), include their minimally invasive isolation procedure, their more primitive cell character without being tumourigenic, their low immunogenicity and their potential autologous application in congenital disorders and when cryopreserved in adulthood. This chapter gives an overview of the biology of AF-MSCs and WJMSCs, and their regenerative potential based on the results of recent preclinical and clinical studies. In the end, open questions concerning the use of WJ-MSCs and AF-MSCs in regenerative medicine will be emphasized.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pränatale Medizin |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Jörger, Marianne, Oppliger, Byron, Müller, Martin (A), Surbek, Daniel, Schoeberlein, Andreina |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1521-6934 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Andreina Schoeberlein |
Date Deposited: |
09 Feb 2016 09:37 |
Last Modified: |
29 Mar 2023 23:34 |
Publisher DOI: |
10.1016/j.bpobgyn.2015.07.006 |
PubMed ID: |
26482184 |
BORIS DOI: |
10.7892/boris.75195 |
URI: |
https://boris.unibe.ch/id/eprint/75195 |
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