Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid

Jörger Messerli, Marianne; Marx, Caterina; Oppliger, Byron; Müller, Martin; Surbek, Daniel; Schoeberlein, Andreina (2016). Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid. Best Practice & Research Clinical Obstetrics & Gynaecology, 31, pp. 30-44. Elsevier 10.1016/j.bpobgyn.2015.07.006

[img] Text
Joerger-Messerli2015.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (335kB) | Request a copy

The discovery of mesenchymal stem cells (MSCs) in perinatal sources, such as the amniotic fluid (AF) and the umbilical connective tissue, the so-called Wharton's jelly (WJ), has transformed them into promising stem cell grafts for the application in regenerative medicine. The advantages of AF-MSCs and WJ-MSCs over adult MSCs, such as bone marrow-derived mesenchymal stem cells (BMMSCs), include their minimally invasive isolation procedure, their more primitive cell character without being tumourigenic, their low immunogenicity and their potential autologous application in congenital disorders and when cryopreserved in adulthood. This chapter gives an overview of the biology of AF-MSCs and WJMSCs, and their regenerative potential based on the results of recent preclinical and clinical studies. In the end, open questions concerning the use of WJ-MSCs and AF-MSCs in regenerative medicine will be emphasized.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pränatale Medizin

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Jörger Messerli, Marianne; Oppliger, Byron; Müller, Martin; Surbek, Daniel and Schoeberlein, Andreina

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1521-6934

Publisher:

Elsevier

Language:

English

Submitter:

Andreina Schoeberlein

Date Deposited:

09 Feb 2016 09:37

Last Modified:

27 Mar 2019 10:25

Publisher DOI:

10.1016/j.bpobgyn.2015.07.006

PubMed ID:

26482184

BORIS DOI:

10.7892/boris.75195

URI:

https://boris.unibe.ch/id/eprint/75195

Actions (login required)

Edit item Edit item
Provide Feedback