Sitjà Bobadilla, Ariadna; Schmidt-Posthaus, Heike; Wahli, Thomas; Holland, Jason W.; Secombes, Chris J. (2015). Fish Immune Responses to Myxozoa. In: Okamura, Beth; Gruhl, Alexander; Bartholomew, Jerri L. (eds.) Myxozoan Evolution, Ecology and Development (pp. 253-280). Cham: Springer 10.1007/978-3-319-14753-6_14
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Myxozoans evoke important economic losses in aquaculture production, but there is almost a total lack of disease control methods as no vaccines or commercial treatments are currently available. Knowledge of the immune responses that lead to myxozoan elimination and subsequent disease resistance is vital for shaping the future development of disease control measures. Different fish immune factors triggered by myxozoan parasites are reviewed in this chapter. Detailed information on the phenotypic and underlying molecular aspects of innate and adaptive responses, at both cellular and humoral levels, is provided for some well-studied fishmyxozoan systems. The importance of the local immune response, mainly at mucosal sites, is also highlighted. Myxozoan tactics to disable or avoid immune responses, such as modulation of immune gene transcription and immune evasion, are also reviewed. The existence of innate and acquired resistance to some myxozoan species suggest promising possibilities for controlling myxozooses through immune-based strategies, such as genetic selection for host resistance, vaccination, immune therapies and administration of immunostimulants.
Item Type: |
Book Section (Book Chapter) |
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Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI) |
UniBE Contributor: |
Schmidt-Posthaus, Heike and Wahli, Thomas |
Subjects: |
600 Technology > 630 Agriculture 500 Science > 590 Animals (Zoology) 600 Technology > 610 Medicine & health |
ISBN: |
978-3-319-14752-9 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Heike Schmidt Posthaus |
Date Deposited: |
09 Feb 2016 15:13 |
Last Modified: |
11 Feb 2016 09:27 |
Publisher DOI: |
10.1007/978-3-319-14753-6_14 |
Uncontrolled Keywords: |
Immune Evasion, Host resistance, Innate response, Adaptive Response, Transcriptional modulation, Histopathology |
BORIS DOI: |
10.7892/boris.75334 |
URI: |
https://boris.unibe.ch/id/eprint/75334 |