Taghizadeh, Elham; Reyes, Mauricio; Zysset, Philippe; Latypova, Adeliya; Terrier, Alexandre; Büchler, Philippe (2016). Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration. Annals of biomedical engineering, 44(8), pp. 2505-2517. Springer 10.1007/s10439-016-1551-4
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Taghizadeh et al. - Annals of biomedical engineering - 2016(2).pdf - Published Version Available under License Publisher holds Copyright. Download (3MB) | Preview |
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Image-based modeling is a popular approach to perform patient-specific biomechanical simulations. Accurate modeling is critical for orthopedic application to evaluate implant design and surgical planning. It has been shown that bone strength can be estimated from the bone mineral density (BMD) and trabecular bone architecture. However, these findings cannot be directly and fully transferred to patient-specific modeling since only BMD can be derived from clinical CT. Therefore, the objective of this study was to propose a method to predict the trabecular bone structure using a µCT atlas and an image registration technique. The approach has been evaluated on femurs and patellae under physiological loading. The displacement and ultimate force for femurs loaded in stance position were predicted with an error of 2.5% and 3.7%, respectively, while predictions obtained with an isotropic material resulted in errors of 7.3% and 6.9%. Similar results were obtained for the patella, where the strain predicted using the registration approach resulted in an improved mean squared error compared to the isotropic model. We conclude that the registration of anisotropic information from of a single template bone enables more accurate patient-specific simulations from clinical image datasets than isotropic model.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Computational Bioengineering 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued] |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Taghizadeh, Elham, Reyes, Mauricio, Zysset, Philippe, Büchler, Philippe |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology > 620 Engineering |
ISSN: |
0090-6964 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Philippe Büchler |
Date Deposited: |
17 Feb 2016 10:32 |
Last Modified: |
01 Jul 2024 09:49 |
Publisher DOI: |
10.1007/s10439-016-1551-4 |
PubMed ID: |
26790866 |
Uncontrolled Keywords: |
Anisotropy; Femur; Finite element analysis (FEA); Patella; Trabecular bone |
BORIS DOI: |
10.7892/boris.75592 |
URI: |
https://boris.unibe.ch/id/eprint/75592 |
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