p73 regulates basal and starvation-induced liver metabolism in vivo

He, Zhaoyue; Agostini, Massimiliano; Liu, He; Melino, Gerry; Simon, Hans-Uwe (2015). p73 regulates basal and starvation-induced liver metabolism in vivo. OncoTarget, 6(32), pp. 33178-33190. Impact Journals LLC 10.18632/oncotarget.5090

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As a member of the p53 gene family, p73 regulates cell cycle arrest, apoptosis, neurogenesis, immunity and inflammation. Recently, p73 has been shown to transcriptionally regulate selective metabolic enzymes, such as cytochrome c oxidase subunit IV isoform 1, glucose 6-phosphate dehydrogenase and glutaminase-2, resulting in significant effects on metabolism, including hepatocellular lipid metabolism, glutathione homeostasis and the pentose phosphate pathway. In order to further investigate the metabolic effect of p73, here, we compared the global metabolic profile of livers from p73 knockout and wild-type mice under both control and starvation conditions. Our results show that the depletion of all p73 isoforms cause altered lysine metabolism and glycolysis, distinct patterns for glutathione synthesis and Krebs cycle, as well as an elevated pentose phosphate pathway and abnormal lipid accumulation. These results indicate that p73 regulates basal and starvation-induced fuel metabolism in the liver, a finding that is likely to be highly relevant for metabolism-associated disorders, such as diabetes and cancer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

He, Zhaoyue; Liu, He and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1949-2553

Publisher:

Impact Journals LLC

Language:

English

Submitter:

Debora Scherrer

Date Deposited:

03 Feb 2016 13:21

Last Modified:

08 Sep 2017 10:26

Publisher DOI:

10.18632/oncotarget.5090

PubMed ID:

26375672

Uncontrolled Keywords:

autophagy; liver; metabolism; p73; starvation

BORIS DOI:

10.7892/boris.75856

URI:

https://boris.unibe.ch/id/eprint/75856

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