A retrospective study of 1- versus 2-cm excision margins for cutaneous malignant melanomas thicker than 2 mm.

Hunger, Robert; Angermeier, Sarina; Seyed Jafari, Seyed Morteza; Ochsenbein, Adrian; Shafighi, Maziar (2015). A retrospective study of 1- versus 2-cm excision margins for cutaneous malignant melanomas thicker than 2 mm. Journal of the American Academy of Dermatology, 72(6), pp. 1054-1059. Elsevier 10.1016/j.jaad.2015.03.029

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BACKGROUND

Most guidelines recommend at least 2-cm excision margin for melanomas thicker than 2 mm.

OBJECTIVE

We evaluated whether 1- or 2-cm excision margins for melanoma (>2 mm) result in different outcomes.

METHODS

This is a retrospective cohort study on patients with melanomas (>2 mm) who underwent tumor excision with 1-cm (228 patients) or 2-cm (97 patients) margins to investigate presence of local recurrences, locoregional and distant metastases, and disease-free and overall survival.

RESULTS

In all, 325 patients with mean age of 61.84 years and Breslow thickness of 4.36 mm were considered for the study with a median follow-up of 1852 days (1995-2012). There was no significant difference in the frequency of locoregional and distant metastasis between the 2 groups (P = .311 and .571). The survival analysis showed no differences for disease-free (P = .800; hazard ratio 0.948; 95% confidence interval 0.627-1.433) and overall (P = .951; hazard ratio 1.018; 95% confidence interval 0.575-1.803) survival.

LIMITATIONS

The study was not prospectively randomized.

CONCLUSIONS

Our study did not show any significant differences in important outcome parameters such as local or distant metastases and overall survival. A prospective study testing 1- versus 2-cm excision margin is warranted.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

 Hunger, Robert, Jafari, Morteza, Ochsenbein, Adrian, Shafighi, Maziar

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0190-9622

Publisher:

 Elsevier

Language:

 English

Submitter:

 Andrea Studer-Gauch

Date Deposited:

 29 Feb 2016 15:43

Last Modified:

 05 Dec 2022 14:52

Publisher DOI:

 10.1016/j.jaad.2015.03.029

PubMed ID:

 25877659

Uncontrolled Keywords:

 disease-free survival; margin of excision; melanomas thicker than 2 mm; metastases; overall survival; recurrences

BORIS DOI:

 10.7892/boris.76286

URI:

 https://boris.unibe.ch/id/eprint/76286

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