Zecca, Chiara; Mainetti, Carlo; Blum, Roland; Gobbi, Claudio (2015). Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection--a case report. BMC neurology, 15(249), p. 249. BioMed Central 10.1186/s12883-015-0504-0
|
Text
Blum 1.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
BACKGROUND
Glatiramer acetate is worldwide used as first line treatment in relapsing remitting multiple sclerosis. Local skin reactions associated with glatiramer acetate are common, however, only isolated cases of severe local injection site reactions known as Nicolau Syndrome have been reported so far.
CASE PRESENTATION
We describe the case of a recurrent Nicolau Syndrome occurred during longstanding glatiramer acetate treatment in a woman with multiple sclerosis. The haemorrhagic patch necrotized and was treated locally as a deep second degree burn with excision of dead skin tissue and was healed. Treatment with glatiramer acetate was definitely suspended.
CONCLUSIONS
GA injections can be complicated by isolated or recurrent Nicolau Syndrome, a potentially life-threatening condition of which neurologists should be aware.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Blum, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1471-2377 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
19 Feb 2016 12:43 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.1186/s12883-015-0504-0 |
PubMed ID: |
26630967 |
BORIS DOI: |
10.7892/boris.76598 |
URI: |
https://boris.unibe.ch/id/eprint/76598 |
Actions (login required)
 |
Edit item |